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題 名 | Sertraline與Maprotiline治療重鬱發作之比較=Comparison of the Clinical Efficacy of Sertraline and Maprotiline in Major Depressive Episodes |
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作 者 | 葉啟斌; 魯思翁; 陸汝斌; | 書刊名 | 臺灣精神醫學 |
卷 期 | 13:4 1999.12[民88.12] |
頁 次 | 頁52-61 |
分類號 | 418.214 |
關鍵詞 | 漢氏憂鬱量表; 嚴重型憂鬱症; Sertraline; Maprotiline; Hamilton depression rating scale; Major depressive disorder; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:Sertraline為一高度選擇性血清素(serotonin)回收抑制劑,且為血清 素回收抑制劑中較少與其它藥物有交互作用,而其代謝物又較不具活性者;maprotiline 則為一高度選擇性正腎上腺素(norepinephrine)回收抑制劑,本研究則選擇此兩種完全 不同機轉之藥物,對憂鬱症之療效做一比較。方法:精神科門診或住院患中,取樣評估後 符合DSM-IV重鬱發作之診斷,且其漢氏憂鬱量表(HAM-D)17項得分超過18之38名患者; 經過隨機分派,20名服用Sertraline,18名服用maprotiline,於治療前及治療後之第0、 1、2、3、4、6週分別以漢氏憂鬱量表及整體印象評估表(CGI)予以評量。結果:二組在 療效上並未達顯著差異。結論:兩種作用機轉不同之藥物其療效於本研究中顯示並無不同 ,是否憂鬱症治療之機轉除血清素或正腎上腺素外,尚有其它作用或兩種神經傳導物質彼 此交互作用,未來有待結合其體液中神經傳導物質之前驅物或代謝物之變化情形,做進一 步探討。 |
英文摘要 | Objective:Most antidepressants in the treatment of major depressive episodes involved serotonin and norepinephrine at the same time. To lower the interactions between the two different mechanisms in the treatment of major depressive episodes with one kind of antidepressant, we selected antidepressants with highly selective inhibitor of either serotonin or norepinephrine. This prospective study is designed to compare the clinical efficacy of these two antidepressants in the treatment of major depressive eisodes. Methods: The study subjects met the DSM IV criteria for a major depressive episode and presented with a total hamilton Depression Rating Scale score > 18 on the 17-item scale. They were randomly assigned to receive either sertraline or maprotiline tiline and were assessed with the 17-item HAM-D, and CGI ( Clinical Global Impression) at the start of treatment, weekly for the first four weeks of treatment and finally in the sixth week. Results: Thirty-eight patients with major depressive episodes were enrolled in the study. No statistically significant differences between the two groups were found in reducing HAM-D scores and CGI scores. However, the sertraline group had lower incidence of adverse events including dry mouth, constipation, and somnolence than the maprotiline group. Conclusion: Although sertraline and maprotiline had similar clinical effectiveness in the treatment of major depressive episodes, patients treated with sertraline had a lower incidence of adverse events. (Full Text in Chinese) |
本系統中英文摘要資訊取自各篇刊載內容。