頁籤選單縮合
題 名 | Matrix Metalloproteinase-1 Expression in Betel Quid-associated Oral Cancers |
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作 者 | Chiu, Chang-ta; Lee, Sheng-yang; Wang, Duan-jang; Liu, Young-chau; Chang, Wei-fan; Yen, Ching-yu; Lee, Chin-hai; Liu, Shyun-yeu; | 書刊名 | Journal of Dental Sciences |
卷 期 | 3:2 2008.06[民97.06] |
頁 次 | 頁75-82 |
分類號 | 416.94 |
關鍵詞 | Oral cancer; Betel nut; Metalloproteinase-1; Immunohisto-chemical staining; |
語 文 | 英文(English) |
英文摘要 | Approximately 80%~90% of Taiwanese patients with oral cancer have chewed betel nuts for a long time. Some ingredients of the nuts may mechanically and chemically disrupt the oral mucosa. Matrix metalloproteinase-1 (MMP-1) is considered to be important in degrading the extracellular matrix. Recent studies have shown that the overexpression of MMP-1 is associated with the occurrence, proliferation, and prognosis of oral cancer as well as lymph node metastasis. Most published studies related to MMP-1 have involved patients with oral cancer from outside of Taiwan, and few have concentrated on patients from Taiwan, who are often habitual betel nuts chewers. Therefore, this research, is aimed at patients in Taiwan, analyzed the MMP-1 expression of oral cancer of the patients. The Department of Oral and maxillofacial Surgery of Chi-Mei Medical Center specifically studied 30 patients with oral cancer and a history of betel nut chewing and their relation to MMP-1 expression. In the immunohistochemical staining analysis, MMP-1 expression was higher in the epithelium of tumor tissues in 19 of 30 patients (63.3%). After further statistical analysis (Fisher's exact test), MMP-1 expression has shown to be stronger in late stages (stages III and IV) than in early stages (stages I and II). In addition, MMP-1 expression also increased with increasing lymph node metastasis staging (from N₀ through N₁ to N₂) and differentiation grade (from G₁ through G₂ to G₃). These/results prove the significant role of MMP-1 in betel nut chewing-associated oral cancer, tumor growth, tumor differentiation, and lymph node metastasis. |
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