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題 名 | G蛋白與精神疾病=G Protein and Mental Disorders |
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作 者 | 陳益乾; | 書刊名 | 醫學研究 |
卷 期 | 17:2 1996.09[民85.09] |
頁 次 | 頁61-76 |
分類號 | 415.972 |
關鍵詞 | G蛋白; 神經介質; 受體; 訊息轉換; 受動器; 精神疾病; 精神藥物; G protein; Neurotransmitter; Recetpor; Signal transduction; Effector; Mental disorder; Psychotropic drug; |
語 文 | 中文(Chinese) |
英文摘要 | G proteins are a family of guanine nucleotide-binding proteins which consist of an α-subunit and inseparable β, γ-subunit complex. The heterotrimeric G protein play a pivotal role in postreceptor information transduction that carry information received at cellular surface to cellular effector systems. G protein-mediated signal transduction is initiated by ligand-bound receptor. This activated receptor is able to interact with G protein and promotes the exchange of GDP, bound to the α-subunit, for GTP and subsequent dissociation of α-GTP complex from βγcomplex heterodimer. Gα-GTP is able to bind and regulate the appropriate effector systems. The mechanism is inactivated by hydrolysis of α-GDP via GTPase. Then α subunit reassociates with theβγcomplex and the system returns to its resting state. These G-protein-mediated cascades regulate both convergence and divergence of and neural activity. G-proteins form the basis of signal integration in CNS, endowing the neuron with a large degree of functional diversity. Abnormalities in the function and expression of G proteins have been implicated in a variety of pathophysiologic states and a number of available psychotropic drugs affect G proteins. To understand the mechanism of G protein-modulating neuronal activity would help us to understand the complexities and function of the nervous system. In this article, the author will discuss how the G protein to influence the pathophysiology of major mental disorders. |
本系統中英文摘要資訊取自各篇刊載內容。