頁籤選單縮合
題名 | 鼻腔及副鼻竇之惡性黑色素腫瘤=Malignant Melanoma of Nasal Cavity and Paranasal Sinuses |
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作者 | 練淑娟; 許志宏; 吳政德; 林清榮; Lien, Shu-chuan; Shu, Chih-hung; Wu, Jeng-de; Lin, Ching-zong; |
期刊 | 中華民國耳鼻喉科醫學會雜誌 |
出版日期 | 19980400 |
卷期 | 33:2 1998.04[民87.04] |
頁次 | 頁22-27 |
分類號 | 416.871 |
語文 | chi |
關鍵詞 | 黏膜惡性黑色素瘤; 鼻腔; 副鼻竇; Mucosal malignant melanoma; Nasal cavity; Paranasal sinus; |
中文摘要 | 背景:原發於鼻腔及副鼻竇之黏膜惡性黑色素瘤是一極為少見且預後不好的疾病。 本報告的目的乃是針對鼻腔及副鼻竇黏膜惡性黑色素瘤的病人,就其臨床病程做一回溯性探 討。 方法:本院耳鼻喉部收集民國71年9月至86年4月底至本部就診追蹤的病例,就病人 的年紀、性別、初發症狀、腫瘤位置、分期、黑色素之有無、治療方法、局部復發之有無合 併頸部或遠端轉移、存活率,加以分析。且將20年來的文獻報告做一回顧與探討。 結果:本報告共收集9個病例,7男2女,追蹤期間從12個月至107個月不等。平均 年齡63歲。主訴多為單側鼻塞、鼻涕帶血絲及膿鼻涕為主。經組織切片證實為惡性黑色素 腫瘤。其中6例屬臨床分期第一期,1例屬第二期,2例屬第三期。其中3例接受手術治療, 4例接受手術及術後放射線治療,1例接受手術及術後化學藥物治療,而1例僅接受支持療 法。追蹤到民國86年4月,9例有5例仍存活。而9例中存活超過5年的有3例。整體而 言,預後不佳。 結論:鼻腔及副鼻竇之黏膜惡性黑色素瘤是一極為少見且預後不好的疾病。治療的方法 以手術治療或合併放射治療為主。治療失敗的原因多為不能控制的局部復發或合併遠端轉 移。因此病人均需長期且定時追蹤。(中耳醫誌1998; 33:120-125。) |
英文摘要 | Background: Primary malignant melanoma of the nose and paranasal sinus is a rare disease with poor prognosis. The purpose of this study was to collect and analyze clinical data of patients with this rare disease. Methods: Nine patients were used as study subjects. Age, sex, tumor location, tumor stage, melanin level, treatment regimen, local recurrence, neck metastasis and distant metastasis were analyzed. Results: Study subject included seven men and two women. The duration of follow up varied from 12 to 107 months. The average age was 63 years, with a range of 38 to 71 years old. Chief complaints included unilateral nasal obstruction, blood tinged rhinorrhea and purulent rhinorrhea. Malignant melanoma was proved by histology. Six patients were grouped as stage I, 1 was grouped as stage Ⅱ, and 2 were grouped as stage Ⅲ. Among these patients, 3 underwent surgery, 4 underwent surgery with adjuvant post-operation radiotherapy., 1 underwent with surgery with post- operation chemotherapy and 1 received supportive care only. These patients were followed until April, 1997. Among the 9 patients, five were still alive. Three of these patients survived longer than 5 years. Conclusion: Prognosis of the patients with nasosinal malignant melanoma is poor. Treatment of choice is radical surgery or surgery combined with post-operation radiotherapy. The primary causes of failure are uncontrolled local recurrence and distant metastasis. Patients require regular follow up if survival is to be maximized. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。