頁籤選單縮合
題名 | Estimating the Distribution of Age at Onset from Case-Control Family Data= |
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作者 | Bagiella,Emilia; Rabinowitz,Daniel; |
期刊 | Statistica Sinica |
出版日期 | 20001000 |
卷期 | 10:4 2000.10[民89.10] |
頁次 | 頁1179-1198 |
分類號 | 410.028 |
語文 | eng |
關鍵詞 | Efficiency; Lynden-bell estimator; Multiplicative intercept; One sample problem; Truncated data; |
英文摘要 | Motivated by a design for discovering associations between inherited childhood risk factors and adult-onset disease, the problem of estimating the distribution of age at onset of the disease from a case-control sample of subjects who have and have not yet experienced onset is examined. An embedding of the distribution function of age at onset in a multiplicative intercept model simplifies estimation by allowing the distribution function of age at enrollment to be conditioned out of the likelihood. A class of estimators of the distribution function of age at onset is developed and it is argued that a member of the class is efficient. Standard error calculations and an approach to approximating the efficient member of the class are described. |
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