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題 名 | 天王補心丹對大白鼠被動迴避學習反應之影響=Effects of Tien-Wang-Pu-Hsin-Dang on the Passive Avoidance Task in Rats |
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作 者 | 謝明村; 吳啟瑞; 劉淑鈴; 闕甫伃; 洪啟賦; | 書刊名 | 中國醫藥學院雜誌 |
卷 期 | 6:2 1997.09[民86.09] |
頁 次 | 頁97-107 |
分類號 | 414.5 |
關鍵詞 | 天王補心丹; 被動迴避學習反應; Tien-wang-pu-hsin-dang; Passive avoidance task; Scopolamine; Cycloheximide; |
語 文 | 中文(Chinese) |
中文摘要 | 王王補心丹主治「思慮過度,心血不足,怔忡健忘,心口多汗,大便或秘或溏, 口舌生瘡等證」,方中以生地、玄參、麥冬及天冬滋陰制火為君,人參及當歸補益氣血為臣 ,棗仁、柏子仁、丹參、茯苓、遠志、五味子養血斂心、鎮心安神為佐,桔梗載藥入心為使 。因此,本研究將天王補心丹分為君、臣、佐、使及全方等五組,以被動迴避反應及自發運 動量來探討天王補心丹對 scopolamine 及 cycloheximide 所誘發學習記憶障礙之作用及 方劑組成與主治間之關連性。一次給藥,對scopolamine 誘發學習獲得障礙及 cycloheximide 誘發記憶鞏固障礙,僅全方組具改善作用;至於對大白鼠自發運動量,全方 組具降低大白鼠自發運動量之作用, 但對電痛閾值則各組均不影響。 一週連續給藥, 對 scopolamine 誘發學習獲得障礙及 cycloheximide 誘發記憶鞏固障礙均具改善作用, 其中 以全方組較為明顯;其次在自發運動量,全方組具增加大白鼠自發運動量之作用,但對電痛 閾值則不影響。最後,全方組改善cycloheximide 誘發記憶鞏固障礙之作用,可被 scopolamine 及 8-OHDPAT 所拮抗,為 ritanserin 所增強。綜合研究結果,顯示天王補心 丹全方組,一次給藥具改善學習記憶作用,而其作用部份因鎮靜之作用所致;一週連續給藥 對學習獲得及記憶鞏固障礙均有明顯之改善作用,而其作用機轉可能與增強中樞 cholinergic system 之活性及 protein synthesis、降低 serotonergic system 之活性有關。 |
英文摘要 | In this study, we divided the Tien-Wang- Pu-Hsin-Dang(abbr. as TWP) into five groups:(I)Chun was consisted of Rehmanniae Radix, Schrophulariae Radix, Ophiopogonis Tuber and Asparagi Radix. (II). Chen was consisted of Ginseng Radix and Angelicae Sinensis Radix. (III) Tso was consisted of Zizyphi Semen, Thujae Orientalis Semen, Salivae Miltiorrhizae Radix, Hoelen, Polygalae Radix and Schizandrae Fructus. (IV) Shih was consisted of Platycodi Radix. (V) TWP was consisted of the above four groups. We attempted to investigate the effect of five groups on scopolamine-induced and cycloheximide-induced impairment of passive avoidance response and locomotor activity in rats. After acute treatment, only V and V could improved the scopolamine-induced and cycloheximide- induced deficit, and the former was better than the latter. After one-week consecutive treatment, five groups could improved the scopolamine-induced and cycloheximide-induced deficit, and the former was better than the latter. After one-week consecutive treatment, five groups could improved the scopolamine-induced and cycloheximide-induced deficit, and V was better than the others. Whereas, V decreased the locomotor activity after acute treatment and increased the locomotor activity after one-week consecutive treatment in rats. But five groups did not change the threshold of vocalization with electric foot-shock in rats. Furthermore, the memory improvement of V on the cycloheximide-induced deficit was antagonized by scopolamine and 8-OHDPAT, and was potentiated by ritanserin. These results are shown that TWP produce memory improvement in acute treatment, partially due to possess sedative effect. The learning and memory improvement effect of TWP after oneweek consecutive treatment may be due to the increase in cholinergic activity and protein synthesis, and the decrease in serotonergic activity. |
本系統中英文摘要資訊取自各篇刊載內容。