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題 名 | Minimal Change Nephrotic Syndrome Associated with Malignant Thymoma: Case Report and Literature Review=惡性胸腺瘤併發微小變化型腎病徵候群:病例報告及文獻回顧 |
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作 者 | 李華誠; 鄭元富; 莊峰榮; 陳靖博; 許國泰; | 書刊名 | 長庚醫學 |
卷 期 | 24:9 2001.09[民90.09] |
頁 次 | 頁576-581 |
分類號 | 415.812 |
關鍵詞 | 微小變化型腎絲球腎炎; 腎病徵候群; 胸腺瘤; 環孢素; Minimal change glomerulonephritis; Nephrotic syndrome; Thymoma; Cyclosporin; |
語 文 | 英文(English) |
英文摘要 | We report on a patient with nephrotic syndrome with myasthenia gravis and malignant thymoma status post thymectomy and radiotherapy. This 44-year-old woman underwent a thymectomy and localized radiotherapy for invasive thymoma in 1991. She also took azathioprine and pyridostigmine regularly for the control of her symptoms of myasthenia gravis following thymectomy. Neither evidence of recurrence of myasthenia gravis, nor enlargement of residual thymoma was noted following treatment in 1991. Unfortunately, this patient developed a pronounced nephrotic syndrome in 1999, a renal biopsy revealing a minimal-change glomerulonephritis as being present. The patient entered remission subsequent to steroid and cyclosporin therapy, whereas many previously-reported cases of a similar nature either died or remained with a persistent proteinuria. Herein, we review the literature pertaining to examples of nephrotic syndrome for those patients diagnosed with malignant thymoma, and discuss the possible mechanisms for this association, and emphasize the need for the aggressive treatment of the condition, recommending the early use of steroids and cyclosporins. |
本系統中英文摘要資訊取自各篇刊載內容。