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題名 | Synthesis and Antifungal Activities of ω-[4-Aryl-5-(1-phenyl-5-methyl-1,2,3-triazol-4-yl)-1,2,4-triazol-3-thio]-ω-(1H-1,2,4-triazol-1-yl)acetophenones= |
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作者 | 褚長虎; 惠新平; 張艷; 張自義; 李之春; 廖仁安; Chu, Chang-hu; Hui, Xin-ping; Zhang, Yan; Zhang, Zi-yi; Li, Zhi-chun; Liao, Ren-an; |
期刊 | Journal of the Chinese Chemical Society |
出版日期 | 20010200 |
卷期 | 48:1 2001.02[民90.02] |
頁次 | 頁121-125 |
分類號 | 346.01 |
語文 | eng |
關鍵詞 | 1H-1,2,4-triazole; 1,2,3-triazole; Thiosemicarbazide; Antifungal activity; |
英文摘要 | New 4-aryl-5-(1-phenyl-5-methyl-1,2,3-triazol-4-yl)-1,2,4-triazol-3-thiones 3 have been synthesized by the intramolecular cyclization of 4-aryl-1-(1-phenyl-5-methyl-1,2,4-triazol-4-formyl)thiosemicarbazides 2 with an 8% NaOH solution, and then 3 reacted with w-bromo-w-(1H-1,2,4-triazol-1-yl)acetophenone to afford w-[4-aryl-5-(1-phenyl-5-methyl-1,2,3-triazol-4-yl)- 1,2,4-triazol-3-thio]-w-(1H-1,2,4-triazol-1-yl)-acetophenones 4. The preliminary biological test showed that the representative compounds possess some antifungal activities. |
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