頁籤選單縮合
題名 | Transformation of Ginsenosides Rg1 and Rb1, and Crude Sanchi Saponins by Human Intestinal Microflora= |
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作者 | 林美智; 王光昭; 李水盛; Lin, Mei-chih; Wang, Kuang-chao; Lee, Shoei-sheng; |
期刊 | Journal of the Chinese Chemical Society |
出版日期 | 20010200 |
卷期 | 48:1 2001.02[民90.02] |
頁次 | 頁113-120 |
分類號 | 341.91 |
語文 | eng |
關鍵詞 | Sanchi saponins; Human microflora; Microbial transformation; 20R-ginsenoside Rh1; 20(22)Z-ginsenoside Rh4; |
英文摘要 | Fractions major in ginsenosides Rg1 and Rb1 from Sanchi saponins were transformed by human fecal flora. This study yielded the corresponding aglycone, protopanaxatriol, in 49.4% from Rg1, protopanaxadiol 20-O-glucoside in 54.8% from Rb1, and dihydroprotopanaxadiol 20-O-glucoside in 87.6% from dihydro Rb1, by incubation with healthy feces for 70 h in subgram level. Nevertheless large-scale incubation of crude Sanchi saponins revealed the complete biotransformation of Rb1 and the almost unchanged Rg1. A small amount of Rg1 was found to be converted into 20R-ginsenoside Rh1 and its dehydration product, 20(22)Z-ginsenoside Rh4. |
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