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頁籤選單縮合
題 名 | Sequence Analysis of Transforming Growth Factor-beta Type Ⅰ Receptors (TGFβ-RI) in Non-neoplastic and Neoplastic Hepatocytes=肝細胞中第一型貝他轉化生長因子受體的基因系列分析 |
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作 者 | 羅時燕; 朱世樑; 賴孟君; 張順浪; 雷永耀; 張泰階; | 書刊名 | 慈濟醫學 |
卷 期 | 11:2 1999.06[民88.06] |
頁 次 | 頁115-123 |
分類號 | 414.8 |
關鍵詞 | 肝癌; 第一型貝他轉化生長因子受體; 絲胺酸; 蘇胺酸活化酵素結構區域; Hepatoma; Transforming growth factor-beta type Ⅰ receptors; Serine; Threonine kinase domains; |
語 文 | 英文(English) |
中文摘要 | 目的:分析在肝癌細胞與正常肝細胞中第一型貝他轉化生長因子受體(於絲胺酸/ 蘇胺酸活化酵素結構區域 ) 的基因系列。 材料與方法:八個肝癌病人身上肝癌組織及週邊 正常肝組織被用來分析。組織內所有核糖核酸經萃取後,逆轉錄成互補去氧核糖核酸,經過 聚合酵素連鎖反應, 第一型貝他轉化生長因子受體 (於絲胺酸 / 蘇胺酸活化酵素結構區域 ) 的基因系列便可決定。 結果:(1) 在八個肝癌病人中,他們 Alk-1 的表現 (於絲胺酸 / 蘇胺酸活化酵素結構區域 ),在肝癌組織或週圍正常肝組織,沒有序列的差異。(2) 在我們 所分析的所有肝組織檢體中,無論 Alk-l、Alk-2、Alk-5 的絲胺酸 / 蘇胺酸活化酵素結構 區域都沒有基因顯著刪除或嵌入的現象。(3) 肝細胞中 Alk-l 的絲胺酸 / 蘇胺酸活化酵素 結構區域序列上有三個核��酸不同於其它組織 Alk-l 的絲胺酸 / 蘇胺酸活化酵素結構區域 序列。 結論:我們的結果顯示第一型貝他轉化生長因子受體的突變 (至少在絲胺酸 / 蘇胺 酸活化酵素結構區域 ),不同於第二型貝他轉化生長因子受體,不是肝癌發生的原因。另外 ,我們的結果也顯示,在肝細胞中 Alk-l 的絲胺酸 / 蘇胺酸活化酵素結構區域有特定的序 列。 |
英文摘要 | Objective: To analyze the genetic sequence(s) of transforming growth factor-beta receptor type I (TGFfi-RI) serine/threonine kinase domain in non-neoplastic and neoplastic hepatocytes. Materials and Methods: Eight sets ofhepatoma and adjacent normal liver tissues from the same patients were analyzed. The total RNAs extracted from various tissues were converted into cDNAs using oligo-d(T) primer. The genetic sequence(s) of the TGFfi-RI serine/threonine kinase domain were determined after the PCR amplification of these cDNAs. Results: (1) No sequence variation in the ALK-I (activin receptor-like kinase) serine/threonine kinase domain was observed between hepatoma and adjacent normal liver tissues in eight pairs of samples. (2) There was no deletion or insertion in the serine/threonine kinase domains of ALK-I, ALK-2, andALK-5 in the samples analyzed. (3) Three nucleotides in the sequence of ALK-I serine/threonine kinase domain derived from the mRNA of liver tissues were different from those mRNAs derived from other tissues. Conclusions: Our data suggest that the variation or mutation of TGFJ3 type I receptors, unlike TGFJ3 type II receptors, is not responsible for the development ofhepatoma, and that there exists a specific sequence in the serine/threonine kinase domain of ALK-I in liver cells. |
本系統中英文摘要資訊取自各篇刊載內容。