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題名 | Clozapine治療中三位精神分裂症患者的死亡原因=Death of Three Patients with Schizophrenia during Clozapine Treatment |
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作者 | 詹宏裕; 張景瑞; 孫效儒; 張達人; Chan, Hung-yu; Chang, Ching-jui; Sun, Hsiao-ju; Chang, Ta-jen; |
期刊 | 臺灣精神醫學 |
出版日期 | 20010600 |
卷期 | 15:2 2001.06[民90.06] |
頁次 | 頁74-80 |
分類號 | 418.21 |
語文 | chi |
關鍵詞 | 急性中毒; 感染; 猝死; Clozapine; Acute intoxication; Infection; Sudden death; |
中文摘要 | 目的:報告三例在使用clozapine期間死亡的精神分裂症個案,檢討clozapine與死亡之相關性和可能之預防措施。病例報告:個案一為21歲女性,吞服clozapine 3600 mg,因心律不整與吸入性肺炎死亡。個案二為35歲男性,服用clozapine 16個月後在白血球數目正常下因細菌性腦膜炎死亡。個案三為52歲女性,服用clozapine兩年半,因病情不穩住院,住院第二天給予clozapine 500 mg與estazolam 4 mg,隔天血壓驟降而猝死。結論:Clozapine服藥過量可能致死,也可能增加猝死的危險,需小心使用。使用clozapine的個案在未測到白血球降低時,是否可能如同免疫系統不足的病人罹患致命之感染,仍有待進一步研究。 |
英文摘要 | Objective: To report three cases of mortality in schizophrenia patients receiving clozapine treatment. Case report: Case A, a 21 year-old female, ingested 3600 mg of clozapine and died of arrhythmia and aspiration pneumonia. Case B, a 35 year-old male, died of the sequelae of Gram negative bacterial meningitis after 16 months of clozapine use. No agranulocytosis was detected. Case C, a 52 year-old female with a 30-month history of clozapine use, received a moderate amount of benzodiazepine initially, with clozapine 500 mg and estazolam 4 mg administered in single dose on the second day after admission. No psychotropic drugs were given subsequently. Sudden death occurred on the third day. Conclusion: Clozapine overdose may be lethal and sudden death may be associated with clozapine treatment. In the case B, we suggest that the possibility that clozapine-treated patients, like immunocompromised hosts, may be more prone to fatal infection even without agranulocytosis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。