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題名 | 雙胞胎研究法在精神疾病之病因探討上的應用=Application of Twin Study Method in Etiology Research of Psychiatric Disorders |
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作者 | 陳為堅; 林喬祥; 郭柏秀; | 書刊名 | 臺灣精神醫學 |
卷期 | 15:2 2001.06[民90.06] |
頁次 | 頁4-21 |
分類號 | 415.95 |
關鍵詞 | 雙胞胎研究; 數量遺傳; 結構方程式模型建構分析; 精神疾病; Twin study; Quantitative genetics; Structural equation modeling; Psychiatric disorders; |
語文 | 中文(Chinese) |
中文摘要 | 由於數量遺傳與分子遺傳這兩大領域的同時快速進展,造就了今日雙胞胎研究在精神疾病之病因探討上更精細與多元的用途。首先,本文回顧雙胞胎研究的基本原理,包括數量遺傳理論,結構方程式模型建構分析與迴歸式分析。其次,我們以精神遺傳學上一些重要的議題為例,說明雙胞胎研究的一些標竿性的新進展,如:不同症候是否由相同基因造成,類別抑或連續取向,共享與非共享環境孰重,基因-環境之互動,縱貫式雙胞胎研究,擴充式雙胞胎設計,與量性基因座之拼圖等。最後,我們則討論雙胞胎研究的困難與挑戰,包括樣本數之估計與實際徵收,兩個基本假設-環境是否完全相等與同卵雙胞胎之遺傳是否完全相同-所面臨的新挑戰,以及台灣的雙胞胎研究現況與困境。 |
英文摘要 | Application of twin studies in elucidating the etiology of psychiatric disorders have become more sophisticated and versatile, thanking mainly to the rapid advancement in both the quantitative and molecular genetics. First, this article reviewed the basic principles of twin study method, including the theory of quantitative genetics, structural equation modeling, and regression analysis of twin data. Next, we highlighted the new insights on some important issues in psychiatric genetics obtained by recent twin studies, such as whether different syndromes share the same genes, dimensional versus categorical approach towards psychopathology, shared versus nonshared environment, gene-environment interplay, longitudinal twin study, extended twin design, and quantitative trait locus mapping. Last, we discussed the difficulties and challenges faced by twin studies, including sample size estimation and sample recruitment, new challenges on two basic assumptions of twin method (the equal environment assumption and the assumption of MZ twins being identical genetically), and the current status of twin studies in Taiwan. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。