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題 名 | 以高張性鹽溶液激發鼻黏膜產生P物質之反應=Substance P Release Evoked by Hypertonic Saline on Nasal Mucosa |
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作 者 | 林明毅; 方深毅; | 書刊名 | 中華民國耳鼻喉科醫學雜誌 |
卷 期 | 34:1 民88.01-02 |
頁 次 | 頁17-21 |
分類號 | 416.852 |
關鍵詞 | 高張性鹽溶液; 鼻黏膜; 神經性炎症反應; P物質; Hypertonic saline; Nasal mucosa; Neurogenic inflammation; Substance P; |
語 文 | 中文(Chinese) |
中文摘要 | 背景:非特定性的刺激物如組織胺、冷空氣、高張性鹽溶液等會激發呼吸道黏膜 之炎症反應,例如高張性鹽溶夜會引起眼睛的神經性炎症和呼吸道的咳嗽,分泌物增多等反 應,其致病機轉至今仍未清楚,高張性鹽溶液可能刺激鼻黏膜感覺神經促其分泌神經胜P物 質,引起續發之神經性炎症反應如腺體的分泌增加,血管的滲透性增加及黏膜下之水腫等。 但至今仍無報告說明感覺神經胜反應於高張性鹽溶液刺激鼻黏膜後的情形。本實驗的目的即 評估對於不同濃度高張性鹽溶液的鼻黏膜激發是否釋出不等量的感覺神經胜P物質。 方法:本實驗選擇10位無鼻黏膜疾病的病人,以不同濃度的高張性鹽溶液刺激右側鼻黏膜後 ,分別收集兩側之鼻分泌液,儲於70度備用。再以放射性免疫分析法檢測其中感覺神經胜P 物質的濃度。 結果:受刺激側之鼻分泌液中感覺神經胜的含量會依高張性鹽溶液之濃度升高而增加,而對 側無反應性增加。 結論:呼吸道黏膜對於高張性鹽溶液的刺激會經由感覺神經釋放P物質,引發黏膜的神經性 炎症反應。 |
英文摘要 | Background: Non-specific stimuli such as histamine, cold air, and hypertonic saline will induce mucosal inflammation of the respiratory tract. Among these, hypertonic saline may also cause ophthalmic neurogenic inflammation, cough, and hypersecretion though its pathogenesis is still unclear. Hypertonic saline may induce the release of a sensory neuropeptide-substance P from the nociceptive nerves, causing subsquent neurogenic inflammation, such as hyper- secretion, vascular hyperpermeability and submucosal edema. There has been no report involving sensory neuropeptide-substance P release induced by hypertonic saline in human nasal mucosa. Thus, we evaluated the substance P response in the nasal secretion after the stimulation of various concentrations of hypertonic saline. Materials and Methods: The right nasal cavity of 10 volunteers without any nasal disease was stimulated by various concentrations of hypertonic saline. Then the nasal secretion of both nasal cavities were individually collected and immmediately stored at -70℃. The concentrations of substance P of the secretion werre measured using radioimmunoassay. Results: There was an increasing trend of substance P concentration in nasal secretion, correlating to the concentration of hypertonic saline in the stimulated nasal cavity. However, there was no significant change in the opposite site. Conclusion: The hypertonic saline may induce neurogenic inflammation of the respiratory mucosa through the substance P release from nociceptive fibers. |
本系統中英文摘要資訊取自各篇刊載內容。