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題 名 | Helicobacter Pylori Infection and Risk of Peptic Ulcer Among Cirrhotic Patients=肝硬化病人中幽門曲狀桿菌感染與消化性潰瘍的關係 |
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作 者 | 王俊雄; 牟聯瑞; 林瑞昌; 郭振源; 張國寬; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 96:1 1997.01[民86.01] |
頁 次 | 頁55-58 |
分類號 | 415.534 |
關鍵詞 | 肝硬化病人; 幽門曲狀桿菌感染; 消化性潰瘍; Helicobacter pylori; Peptic ulcer; Liver cirrhosis; |
語 文 | 英文(English) |
英文摘要 | There is a higher prevalence of peptic ulcer disease in cirrhotic patients than in the general population. Whether Helicobacter pylori is a risk factor for peptic ulcer in cirrhosis remains controversial. The aim of this study was to determine whether there is a significant correlation between H. Pylori infection and peptic ulcer in liver cirrhosis. In a cross-sectional study, 49 cirrhotic patients underwent upper gastrointestinal endoscopy and 75 controls (health examinees) without liver disease were also examined by endoscopy. The presence of H. pylori was assessed by culture, histologic findings and rapid urease test of gastric antrum biopsy specimens. Thirty of the 49 (61 % ) cirrhotic patients had peptic ulcers, as compared to 24 of the 75 (32 % ) controls. The frequency of H. pylori in the antrum in the cirrhotic group was significantly lower than in the control group (39 % vs 69 % ). The presence of H. pylori was more frequent in control patients with gastric (75 % ) and duodenal ulcers (95 % ) than nonulcer control patients (59 % ), whereas the difference between patients with peptic ulcer and nonulcer (40 % vs 37 % ) was not significant in cirrhotic patients. H. pylori was identified in 40 % of the cirrhotic patients with duodenal ulcers compared with 95 % of controls with duodenal ulcers (p < 0.05). Nevertheless, this difference was not significant among patients with a gastric ulcer between the two groups (40 % vs 75 % ). There was no significant difference in the frequency of H. pylori infection among nonulcer patients between the cirrhotic and control groups (37 % vs 59 % ). In conclusion, we found no evidence to substantiate an etiologic role of H. pylori in the development of a duodenal ulcer in cirrhotic patients. |
本系統中英文摘要資訊取自各篇刊載內容。