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題 名 | 豬萎縮性鼻炎巴氏桿菌類毒素菌苗之研發及其效力試驗=Protection Against Swine Atrophic Rhinitis by Vaccination with Pasteurella Multocida Toxoid Bacterin |
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作 者 | 劉正義; 楊寶賢; 簡茂盛; 林正忠; | 書刊名 | 中華民國獸醫學會雜誌 |
卷 期 | 24:4 1998.12[民87.12] |
頁 次 | 頁272-282 |
分類號 | 437.657 |
關鍵詞 | 萎縮性鼻炎; 巴氏桿菌類毒素菌苗; 效力試驗; Atrophic rhinitis; Pasteurella multocida toxin; PMT; Toxoid bacterin; Efficacy test; |
語 文 | 中文(Chinese) |
中文摘要 | 以Pasteurella multocida type D菌株(Liu-48)製備粗製毒素(crude P. multocida toxin; PMTcd),將此PMTcd再製備類毒素(toxoid)並混合Bordetella bronchiseptica及P. multocida type A不活化全菌菌苗使成萎縮性鼻炎(atrophic rhinitis:AR)類毒素菌苗,並以此自製之 菌苗行免疫試驗以評估其效力。自製菌苗經免疫小白鼠及天竺鼠二次後再以PMTcd攻毒, 結果顯示菌苗對小白鼠及天竺鼠皆有保護效力。比較自製菌苗與商品化菌苗免疫懷孕母豬之 移行抗體對仔豬之保護效力。兩試驗組仔豬移行抗體力價以Vero cells行中和試驗測試,並 於一週齡經PMTcd攻毒後,皆無臨床症狀,亦無鼻甲介骨萎縮病變。攻毒後一個月,仔豬 平均增重記錄顯示,兩試驗組的仔豬較陽性對照組高(p<0.05)。自製AR菌苗對仔豬之主 動免疫保護試驗顯示:(甲)母豬免疫,仔豬分別於一週齡、三週齡免疫組及(丁)母豬不 免疫,但仔豬分別於一週齡、三週齡免疫組之仔豬有較高之抗體力價及良好保護;而(乙) 母豬免疫,仔豬只免疫一次之部份仔豬有輕度鼻甲骨萎縮;至於(丙)母豬免疫,仔豬不免 疫組則有較多仔豬出現AR病徵。母豬及仔豬皆無免疫之對照組則最差,仔豬經攻毒後大都 出現AR病徵。各組仔豬在攻毒後一個月及二個月比較增重成長情形,亦顯示甲組最佳,丁 組次之,其他依序為乙組、丙組、對照組最差;且甲、乙、丙、丁各組增重與對照組比較有 顯著性差異(p<0.05),而甲與丁組及乙與丙組間也有顯著性差異(p<0.05)。 |
英文摘要 | By combining PMTcd toxoid with inactivated B. bronchiseptica and P. multocida type A, an experimental atrophic rhinitis (AR) bacterin-toxoid was developed in this study. Immunologic tests were carried out to assess its efficacy. Mice and guinea pigs vaccinated with the AR bacterin- toxoid were proved to have excellent protection after challenged with PMTcd. The piglets born by the vaccinated pregnant sows were shown with high maternal antibody and good protection levels. The average maternal antibody titers in 3 days old and 1 week-old piglets were measured and shown to have successful protection by challenged with PMTcd at 1 week old without showing AR clinical signs and lesions. Prior to and up to 1 month after challenge, the average weight gain of the experimental piglets showed significant difference (p < 0.05) from the positive control ones. Another protection test was also conducted in our studies. Sows and their offspring were divided into 5 groups as the groups A (sows immunized and piglets vaccinated twice a 1 and 3 weeks of age), B (sows immunized but piglets vaccinated only once at 1 week old), C (sows immunized but piglets without vaccinated), D (sows not immunized but piglets vaccinated twice at 1 and 3 weeks of age), and positive control group (sows and piglets without immunized). All the piglets of these 5 groups were challenged with PMTcd at 5 weeks of age. The results showed that group A and D piglets had good antibody response and excellent protection against toxin challenge. Group B and C piglets only possessed uncomplete protection. After challenged, the lesions of AR were evidently seen in some piglets. The piglets from control group showed marked clinical signs and lesions of nasal atrophy after challenge. To compare the weight gains among these experimental and control piglets challenged with PMTcd after 1 month and 2 months, the results showed that the piglets of group A had best growth performance, followed by group D, group B, group C and control group. The weight gain between experimental groups and control group showed significant difference (p < 0.05). Another significant differences between groups A, D and groups B, C (p < 0.05) were also noticed. |
本系統中英文摘要資訊取自各篇刊載內容。