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題 名 | Diethylmaleate Decreased Ascorbic Acid Release Induced by Cerebral Ischemia in Cerebral Cortex of the Anesthetized Rat |
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作 者 | Yang,Chung-shi; Tsai,Pi-ju; Lin,Nai-nu; Kuo,Jon-son; | 書刊名 | 中國生理學雜誌 |
卷 期 | 43:2 2000.06[民89.06] |
頁 次 | 頁49-53 |
分類號 | 415.1 |
關鍵詞 | Ascorbic acid; Diethylmaleate; L-trans-pyrrolidine-2,4-dicarboxylate; Glutamate; Glutathione; Microdialysis; Anesthetized rat; Brain cortex; |
語 文 | 英文(English) |
英文摘要 | The effect of diethylmaleate administration on ascorbic acid release following cerebral ischemia was investigated in anesthetized rat brain cortex. Cerebral ischemia, induced by ligating bilateral common carotid arteries and unilateral middle cerebral artery, significantly increased the extracellular ascorbic acid levels. Diethylmaleate (4 mmoles/kg, i.p.), which has been shown in earlier studies to decrease the ischemia-induced glutamate release, significantly reduced the ischemia-induced ascorbic acid release. The ischemia-induced ascorbic acid release was unaffected by perfusing NMDA receptor antagonist MK 801 (75μM). Additionally, elevated extracellular glutamate levels, achieved by either externally applied glutamate solutions or by perfusing L-trans-pyrrolidine-2,4-dicarboxylate (PDC) (31.4mM and 15.7mM) to inhibit the glutamate uptake transporter, also significantly increased the extracellular ascorbic acid levels. These results suggested that ascorbic acid release in cerebral ischemia might be related to the elevated extracellular glutamate levels, which occurs following cerebral ischemia. |
本系統中英文摘要資訊取自各篇刊載內容。