頁籤選單縮合
題 名 | Long-term Survival and Stage I Breast Cancer Subtypes |
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作 者 | Cheng, Skye Hung-chun; Yu, Ben-long; Horng, Cheng-fang; Tsai, Stella Y.; Chen, Chii-ming; Chu, Nei-min; Tsou, Mei-hua; Lin, Christopher K. J.; Shih, Li-sun; Liu, Mei-ching; | 書刊名 | Journal of Cancer Research and Practice |
卷 期 | 3:1 2016.03[民105.03] |
頁 次 | 頁1-8 |
分類號 | 416.226 |
關鍵詞 | Luminal-like; Triple-negative; HER2 overexpression; Breast cancer subtype; Long-term survivals; |
語 文 | 英文(English) |
英文摘要 | Background: This study is to evaluate the associations between long-term survival and stage I breast cancer by examining the hormonal receptor (HR) and human epidermal growth factor receptor-2 (HER2) status. Materials and methods: A total of 1595 breast cancer patients who were seen from 1990 to 2008 with surgery as first treatment and pathology stage I (T1N0) were included in this study. HR and HER2 status were used to approximate breast cancer subtypes. Additionally, ten-year relapse-free survival (RFS) rate and failure patterns of each subtype were evaluated. Multivariate analyses were performed in each subtype to identify the risk factors of recurrence. Results: Luminal-like (HR positive and HER2 negative) stage I patients showed a 10-year RFS rate of 89.5%, HER2 positive 92.9%, triple negative 91.1%, and unclassified subtype 86.2% (p ¼ 0.089), respectively. The 10-year overall survival was 94.1% in luminal-like subtype, 90.1% in HER2, 94.5% in triple negative, and 85.3% in unclassified subtype. The independent recurrence risk factors in luminal-like subtype were 40 years of age (hazard ratio [HR] 2.2, 95% confidence interval [CI], 1.1e4.4), nuclear grade III (HR 2.7, CI, 1.4e5.3), and tumor >1.5 cm (HR 1.8, CI 1.0e3.4), and in unclassified subtype 40 years of age, tumor >1.5 cm, and adjuvant hormonal therapy. No risk factors were identified in HER2 or triple negative subtype. Conclusions: The factors associated with poor prognosis of stage I breast cancer vary by subtype. No risk factors were identified in HER2 subtype or triple negative patients. Tumor size >1.5 cm, age 40 years and nuclear grade 3 are the risk factors associated with poor prognosis in luminal-like subtype. |
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