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題名 | Facile Solid Phase Synthesis of Octreotide Analogs Using P-Carboxybenzaldehyde as a Novel Linker to Anchor Fmoc-Threoninol to Solid Phase Resins= |
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作者 | Wu,Ying-ta; Hsieh,Hsing-pang; Wu,Chi-yu; Yu,Hui-ming; Chen,Shui-tein; Wang,Kung-tsung; |
期刊 | 中央研究院生物化學研究所論文集 |
出版日期 | 19980000 |
卷期 | 24 1998[民87.] |
頁次 | 頁33-34 |
分類號 | 361.4 |
語文 | eng |
關鍵詞 | Facile solid phase synthesis; P-carboxybenzaldehyde; Fmoc-threoninol; Solid phase resins; |
英文摘要 | A new procedure is described for the synthesis of octreotide and its analogs using p-carboxybenzaldehyde as a linker to anchor Fmoc-threoninol to solid phase resins. Fmoc-threoninol reacted with p-carboxybenzaldehyde to form Fmoc- threoninol p-carboxybenzacetal in 95% yield. The Fmoc-threoninol p- carboxybenzacetal was coupled to an amine-resin and octreotides were successfully synthesized with yields of 74-76%. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。