頁籤選單縮合
題 名 | Familial Breast Cancer in Southern Taiwan=南臺灣家族性乳癌 |
---|---|
作 者 | 侯明鋒; 蔡坤寶; 范惠美; 王貞雅; 林玟君; 劉景勳; 林相如; 蔡志仁; 歐陽賦; 李水龍; 張永源; 黃宗人; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 16:8 2000.08[民89.08] |
頁 次 | 頁414-421 |
分類號 | 416.226 |
關鍵詞 | 家族性乳癌; Familial breast cancer; BRCA1; BRCA2; |
語 文 | 英文(English) |
中文摘要 | 本研究主要在評估台灣家族性乳癌與非家族性乳癌, 其病理生物特性 及存活率之差異性,針對在96乳癌家族內的76例家族性乳癌病例其中包含兩例 乳癌第一型基因變異者及四例第二型乳癌基因變異者,與425例非家族性乳癌比 較其組織形態、分級、及臨床表現。 結果顯示家族性乳癌與非家族性乳癌有相 似的年齡及分期,但在6例乳癌基因變異者則有較低的發生年齡(45.1歲比48.9 歲)及乳癌發生於早期,而家族性乳癌在浸潤性管道乳癌與葉狀原位癌的比例與 對照組相似,而粘液性乳癌佔家族性乳癌的6.7%, 而髓狀乳癌則只一例,在組織 分級上,家族性乳癌顯然較非家族性乳癌為高。 在平均追蹤4.5年,5年及10 年的全存活率,在家族性乳癌為69%及61%,而非家族性乳癌則為86%及 64%(P>0.05)。而5年及10年無病存活率在家族性乳癌則為69%及48%,而非家 族性乳癌則為78%及58%(P>0.05),顯然兩組的存活率並無統計的差別。 雖然 家族性乳癌即使在乳癌基因變異者有較年輕年紀及早期發現,甚至有較差的組織 分級,但兩者的預後並未差別,由於有限的家族性乳癌案例,更多的案例及更長 的追蹤可能是必要的。 |
英文摘要 | The purpose of this study is to evaluate whether there are pathobiologic differences and differences in overall rates survival between familial and non-familial breast cancer patients in Taiwan. A retrospective study was performed evaluating 76 familial breast cancer patients in 69 families, which included two BRCA1 related cases and six BRCA2 related cases. Patients were compared with 425 non-familial sporadic cases. Familial breast cancer patients had similar ages and stages as non-familial patients (mean,46.6 years vs 48.9 years, p=0.306 ). However, the familial breast cancer patients with BRCA1 and BRCA2 related cases presented at lower stages (p=0.034) and younger ages than non-familial patients (mean, 45.1 years vs 48.9 years P=0.042). The occurrence of infiltrating ductal carcinoma and lobular carcinoma in situ was not significantly different in the two groups. Mucinous carcinoma was represented with 6.7% (4/76) and 1.3% (1/76) medullary carcinoma. The overall grade of familial breast cancer, including BRCA1 and BRCA2 related cases in 8 inflitrating ductal carcinoma, was significantly higher than that of controls. The mean follow up was 4.5 years for familial breast cancers. Five- and 10-year overall survival rates were 69% and 61% for those with a family history, compared with 86% and 64% for those in the control group (p=0.644). There were no statistically significant differences in disease-free survival rates between the two groups at 5 or 10 years (69% vs 78% in 5 years; 48% vs 58% in 10 years) (p=0.862). Despite the younger ages and earlier stages at presentation in familial breast cancer patients with BRCA1 and BRCA2 related cases, the familial breast cancer patients had higher grade patholobilogic characteristics, but similar prognoses when compared with sporadic breast cancer patients. Owing to the limited number of familial cases in this study, more cases and longer follow up are needed. |
本系統中英文摘要資訊取自各篇刊載內容。