頁籤選單縮合
題 名 | Stem Cell Differentiation and Reduction as a Potential Mechanism for Chemoprevention of Breast Cancer |
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作 者 | 謝靜宜; 張家成; | 書刊名 | 中華藥學雜誌 |
卷 期 | 51:1 1999.02[民88.02] |
頁 次 | 頁15-30 |
分類號 | 415.138 |
關鍵詞 | Stem cell differentiation and inhibition; Chemoprevention mechanisms; Breast cancer; |
語 文 | 英文(English) |
英文摘要 | From laboratory animal studies of genistein and human chorionic gonadotropin, induction of mammary gland differentiation could be a mechanism for chemoprevention. Besides incorporating this strategy into a blueprint for cancer prevention proposed by Weinstein (1991), we have reviewed recently reported mechanisms of action of various chemopreventive agents and potential chemopreventive agents for breast cancer. Furthermore, we described a recently characterized normal human breast epithelial cell type with stem cell characteristics (Type I HBEC). These cells have been shown to be more susceptible to neoplastic transformation than the conventional cell type (Type II HBEC) and could be differentiated into other cell types. This in vitro differentiation model could be useful to identify chemopreventive agents that induce mammary gland differentiation. Our study with two putative breast cancer chemopreventive agents, genistein and vitamin D□, Indeed, shows that these compounds could preferentially inhibit the growth and/or differentiate Type I HBEC. These results support the hypothesis that chemopreventive agents might differentiate and/or inhibit the growth of stem cells, thereby reducing the target cells for neoplastic transformation. |
本系統中英文摘要資訊取自各篇刊載內容。