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題名 | Cryptococcal Meningitis in Systemic Lupus Erythematosus: A Case Report=系統性紅斑性狼瘡併發隱球菌性腦膜炎:一病例報告 |
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作者 | 謝昌勳; 張德明; | 書刊名 | 醫學研究 |
卷期 | 20:6 2000.06[民89.06] |
頁次 | 頁302-307 |
分類號 | 415.695 |
關鍵詞 | 系統性紅斑性狼瘡; 隱球菌性腦膜炎; Systemic lupus erythematosus; Cryptococcal meningitis; |
語文 | 英文(English) |
中文摘要 | 隱球菌性腦膜炎在系統性紅斑性狼瘡是一罕見之併發症。這種伺機性感染的發生可能因於免疫抑制劑之治療或內在性免疫之缺失。此外,由於這種感染是漸進性且臨床上無明顯腦膜刺激症狀,常會被誤認為狼瘡併發中樞系統侵犯。如此將會使臨床醫師更積極使用類固醇來治療,將更增加感染黴菌之危險,而在診斷和治療上之延遲將造成病人死亡或一些長期之後遺症。我們報告一位狼瘡患者併發隱球菌性腦膜炎,且對amphotericin B治療效果良好。 |
英文摘要 | Cryptococcal meningitis is a rare complication of systemic lupus erythematosus (SLE). The development of this opportunistic infection may result from either immunosuppressive therapy or intrinsic immunological defects. Because this infection has an insidious onset without clinical evidence of meningeal signs, it is often mistaken for SLE CNS involvement. This misdiagnosis can lead to more aggressive corticosteroid therapy, which carries an increased risk of fungal infection. A delay in diagnosis and therapy may lead to death or long-term sequelae. We report on a 24-year-old lupus patient who presented with intermittent low-grade fever and headache, which partially respond to antibiotics and corticosteroid initially. The final diagnosis was crypto-coccal meningitis, proved via lumbar puncture. The patient was treated with amphotericin B with good response. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。