頁籤選單縮合
題名 | Impact of Intramarrow Penetration on Vertical Bone Augmentation in Rabbit Calvaria=骨髓內穿通對兔子頭骨垂直骨增生效果的影響 |
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作者 | 董醒任; 杜裕康; | 書刊名 | 臺灣牙周病醫學會雜誌 |
卷期 | 17:2 2012.06[民101.06] |
頁次 | 頁109-123 |
分類號 | 416.95 |
關鍵詞 | 骨髓內穿通; 皮質骨穿孔; 垂直骨增生術; Intramarrow penetration; Decortication; Vertical bone augmentation; |
語文 | 英文(English) |
中文摘要 | 垂直骨增生術(vertical ridge augmentation)常被用來增生骨塉以利植牙或治療嚴重之骨缺損。Simion等學者認為皮質骨穿孔有助於垂直增生:Tinti等學者則未實行此一步驟。皮質骨穿孔是否可促進垂直骨增生,實需長期對照性研究之評估。本實驗以五隻3-4公斤之紐西蘭品系兔子為動物模型,手術將頭骨翻開,骨膜剝離後,頭骨的一邊小心將皮質骨以小號圓形鑽頭鑽孔,另一邊則未鑽孔當做對照組。最後覆上載滿血塊之直徑8mm,內緣高度3.5mm的鈦帽。三個月後將兔子犧牲,取下頭骨,以福馬林formalin固定後,以formic acid脫鈣,然後去掉鈦帽,組織包埋並切片後以H&E及trichrome染色。鈦帽內骨增生的高度以組織測量後(以原頭骨外緣為基底,分別測量鈦帽內左,右及中間部位骨增生的量)用pairt test分析。骨癒合程度以半定量方式評估:0,1,2,3分別代表垂直增生組織中約有o%<25%,25-50%,>50%新骨形成。結果發現進行骨穿孔的部位平均骨增生2.31mm,未穿孔部位平均增生1.77mm,兩者之間有顯著的差異(p=0.038)。骨穿孔或未穿孔部位垂直增生之組織有<25%或25-50%新骨形成,兩者之間無顯著的差異(p=0.178)。在本研究的條件下,骨穿孔似有促進垂直骨增生的效果。是否因為骨髓中之骨先驅細胞的作用,仍需進一步研究。 |
英文摘要 | The goal of the present study was to explore the impact of intra-marrow penetration on vertical bone augmentation in vivo. Five adult male New Zealand white rabbits, weighing 3 to 4 kg were used. Following anesthesia, mid-sagittal incision through the skin of the dorsum of the calvarium was performed. Treatments were divided into two groups: I) skin-periosteal flap with intra-marrow penetration (test) and II) skin-periosteal flap without intra-marrow penetration (control). A circular slit of 1.5 to 2.0 mm depth was prepared on both sides of the calvarium using a trephine drill with a diameter of 8 mm under generous irrigation with saline. The titanium domes (0.5 mm in thickness) were filled with peripheral blood for both treatment groups. After the blood clot has formed, the domes approximate 3.5 mm in inner height, were then placed in each slit by press fit. After three months, the skull bone was retrieved en bloc with the domes in situ for histological analysis. The highest point of the augmented tissue was measured directly with Boley gauge. Bone healing was evaluated by a semi-quantitative bone score according to the relative proportion of newly formed bone in the dome. Differences among means for all experiments were analyzed for statistical significance using Student's t test for matched-pair parametric data. Bone-like tissue formed on cranium in both treatment groups. Mean height of augmented tissue for Group I with decortication and Group II without decortication was 2.3 mm and 1.7 mm, respectively. The degree of vertically augmented bone height was significantly greater in the group with intra-marrow penetration than that of the control group (p=0.038). Most augmented tissue from both Groups contained 25 - 50% new bone. No statistically significant differences in bone score were noted between Groups I and II (p=0.178). In conclusion, under the limit of the preliminary experiment conditions, intramarrow penetration accelerated initial generation of bone height. Future human controlled clinical trials are encouraged to address the ability of decortication to enhance vertical bone augmentation. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。