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題 名 | 血清素第二型受體在憂鬱症及其治療所扮演的角色=The Role of 5-HT[feaf]Receptors in Depression and Its Treatment |
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作 者 | 夏一新; 陸汝斌; | 書刊名 | 臺灣精神醫學 |
卷 期 | 14:2 2000.06[民89.06] |
頁 次 | 頁3-17 |
分類號 | 418.214 |
關鍵詞 | 血清素; 血清素第二型受體; 憂鬱症; 自殺; 抗憂鬱藥物; 電痙攣治療; Serotonin; 5-HT; 5-HT[feaf]receptors; Major depression; Suicide; Antidepressants; Electroconvulsive therapy; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:隨著神經科學知識和技術的發達,憂鬱症的研究重心已發展到血清素受體上,本文的目的在於回顧及整理現今對血清素第二型受體在憂鬱症及其治療所扮演角色的知識。 方法:我們系統性地回顧血清素第二型受體,憂鬱症及自殺的研究,以及血清素第二型受體在抗憂鬱藥物及電痙攣治療作用機轉的研究。 結果:文獻回顧顯示血小板、死後、神經內分泌、神經影像及基因遺傳研究已提供一些證據支持“血清素第二型受體”在憂鬱症病患異常地向上調節,而抗憂鬱治療如抗憂鬱藥物及電痙攣治療則向下調節血清素第二型受體。然而憂鬱症病患血清素第二型受體的向上調節究竟是屬於基因異常傳遞的原發性病因,抑或源自於血清素功能不足的續發性反應,目前還不清楚,尚待進一步釐清。 結論:現有一些證據顯示血清素第二型受體參與憂鬱症病因以及抗憂鬱藥物和電痙攣治療的作用機轉,未來利用先進的神經科學技術從事進一步的研究,勢將增進我們對血清素第二型受體在憂鬱症及其治療所扮演角色的瞭解。 |
英文摘要 | Objective: The purpose of this paper was to review and summarize the current state of knowledge on the role of 5-HT2 receptors in depression and its treatment. Methods: We systematically reviewed studies of 1) 5-HT2 receptor function in depression and 2) 5-HT2 receptor involvement in the mechanism of action of antidepressant agents and electroconvulsive therapy (ECT). Results: We found that that platelet, postmortem, neuroendocrine, neuroimaging and genetic studies provided some evidence to support the hypothesis that 5-HT2 receptors are up-regulated in depressed patients and that both antidepressants and ECT down-regulate the 5-HT2 receptors. However, it remains unclear whether the up-regulation of 5-HT2 receptors in depression is a primary or secondary abnormality. Conclusion: There is some evidence for contribution of 5-HT2 receptors in the pathophysiology of depression and in the mechanism of action of antidepressants and ECT. Further studies with modern neuroscience techniques such as neuroimaging and genetic techniques are needed to enhance our understanding of the role of 5-HT2 receptors in depression. |
本系統中英文摘要資訊取自各篇刊載內容。