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題 名 | Altered Intracellular Calcium Level in Association with Neuronal Death Induced by Lithium Chloride=鋰鹽改變神經細胞內鈣濃度與神經毒性之相關研究 |
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作 者 | 姚智榮; 林啟萬; 蕭水銀; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 98:12 1999.12[民88.12] |
頁 次 | 頁820-826 |
分類號 | 418.21 |
關鍵詞 | 鋰鹽; 神經細胞; 鈣濃度; 神經毒性; Cerebellar granule neuron; Lithium chloride; Intracellular calcium; Survival; |
語 文 | 英文(English) |
英文摘要 | In this study, we examined the effects of lithium chloride (LiCl) on the intracellular calcium levels ([Ca�ヅ��), and the survival of immature and mature cultured cerebellar granule neurons (CGNs) grown in medium containing high (25 mmol/L) or normal (5 mmol/L) potassium (K��) levels. LiCl dramatically reduced [Ca�ヅ�履n immature CGNs maintained in high K��(HK) medium and in those switched to serum containing normal K��(NK) medium for 1 to 2 days. This reduction in [Ca�ヅ�幢ed to massive neuronal death of immature neurons developed in both HK and NK medium. In mature (cultured 5-8 days in vitro) CGNs, LiCl exhibited potent toxicity when cells were grown in HK medium , and led to increased [Ca�ヅ��. Exposing mature CGNs to serum deprivation and normal extracellular K �� conentrations decreased [Ca �� ] �� and induced cell death, while the addition of LiGl in these conditions further decreased [Ca �� ] �� but prevented cell death. The morphologic features revealed by Nomarski optics further confirmed these effects of LiCl on neuronal survival. Together, these findings indicate that the effects of LiCl on [Ca �� ] �� and neuronal death, and the association between [Ca �� ] �� and cell death, depend on the developmental stage of CGNs and the growth conditions to which they are subjected. These findings may help in understanding the mechanism of neurotoxicity of LiCl during therapy. |
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