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題名 | Association of HLA-Te22 Antigen with Anti-nuclear Antibodies in Chinese Patients with Erosive Oral Lichen Planus=國人糜爛型口腔扁平苔癬患者之HLA-Te22抗原和抗核抗體有關 |
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作者 | 孫安迪; 吳英俊; 王拯宗; 劉步遠; 江俊斌; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷期 | 24:2 2000.04[民89.04] |
頁次 | 頁63-69 |
分類號 | 416.94 |
關鍵詞 | 口腔扁平苔癬患者; HLA-Te22抗原; 抗核抗體; Anti-nuclear antibodies; Smooth muscle antibodies; HLA antigens; Erosive oral lichen planus; |
語文 | 英文(English) |
英文摘要 | The purpose of this study was to determine the frequencies of the presence of serum anti-nuclear antibodies (ANA) and smooth muscle antibodies (SMA) in 76 patients with oral lichen planus (OLP), in 77 patients with other oral mucosal diseases, and in 41 healthy control subjects. HLA phenotypes in some of the patients with OLP and recurrent aphthous ulcers (RAU) were determined to show whether there was an association of HLA antigens with the presence of autoantibodies. Indirect immunofluorescence techniques with mouse liver or stomach as the substrate were used to detect the serum ANA or SMA, respectively. The B lymphocytes isolated from peripheral blood were used for HLA typing by means of a standard microcytotoxicity assay. We found that the positive rate of serum ANA in patients with OLP (29%, p < 0.01) , especially in patients with erosive OLP (34%, p < 0.001), was significantly higher than that in the normal control subjects (5%). The frequency of serum SMA in patients with OLP (20%, p < 0.01) , in patients with RAU (17%, p < 0.01) , or in patients with oral squamous cell carcinomas (41%, p < 0.001) was also significantly higher than that in normal control individuals (0%). In the erosive OLP group, the HLA-Te22 antigen occurred more frequently in patients with positive ANA (75%, p < 0.05) than in those with negative ANA (25%). We conclude that there is an association of HLA-Te22 antigen with ANA in Chinese patients with erosive OLP. |
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