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題 名 | 由中藥草中分離能提升輻射治療效果之輻射增敏劑(2)=Screening the Chinese Medicine for Radiation Sensitizers in Radiotherapy for Human Cancers(2) |
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作 者 | 譚世特; | 書刊名 | 中醫藥年報 |
卷 期 | 17:3 1999.05[民88.05] |
頁 次 | 頁243-260 |
分類號 | 418.5 |
關鍵詞 | 癌症治療; 中藥輻射增敏劑; 抗癌中藥; Cancer therapy; Chinese medicine as radiosensitizer; anticancer drugs; |
語 文 | 中文(Chinese) |
中文摘要 | 這是三年計畫的第二年的成果報告。計畫之主要目的在:由中藥 草等天然物之萃取物中篩檢出能使生物細胞增加游離輻射敏感性 者。這些細胞輻射增敏劑有潛力被研發成能提升人類輻射治癌效用 的輻射敏劑(radiosensitizers)。到目前為止的研究成果包括:(一) 建立一套以微生物細胞Deinococcus radiodurans為基礎的快速篩檢步 驟。篩檢條件的考慮要點包括菌株種類,測試時的細胞生理態, 藥物處理條件,及游離輻射劑量等。(二)已檢測出對測試細 胞D.radiodurans有明顯輻射增敏效應的兩個樣品(THKM8605與 THKM75);此成功初步證明所採用的篩檢步驟的有效性。(三) THKM8605與THKM75二化合物的學名及化學構造式已定性。(四) 初步實驗顯示THKM75對癌細胞有選擇性的毒殺效果,特別值得進 一步評估與開發。(五)已純化出與THKM8605與THKM75構造稍 有不同的化合物,分別是THKM8605-1、THKM8605-2與THKM75- 1。這些化合物將為下一年度實驗的對象,以推測與輻射增敏效應有 關的化學構造。 |
英文摘要 | This is the second-year progress report of a 3-year project designed to screen Chinese medicine for components that could sensitize cells to radiation inactivation. The cell radiosensitizers screened out will be used as the starting materials for developing radiosensitizers potentially useful in radiothapy in human cancers. Up to now, we have (a)established a microbe-based screening procedure for cell radiosensitizers; The procedure has been improved by considering the following points:strain, cell physiological state, conditions for drug treatment and for ionizing irradiatiion. (b)identified two samples (THKM8605 and THKM75) capable of displaying profound radiosenssitizing effect; this success demonstrates the usefulness of our screening protocol. (c)determined the scientific names and chemical structures for THKM8605 and THKM75. (d)shown that THKM75 may be cancer-specific in cell cytotoxicity. (e) prepared pure compounds with structures similar to THKM8605 or THKM75; these compounds will be used in the following year to help identify the specific chemical structure (s)responsible for the radiosensitizing effect. |
本系統中英文摘要資訊取自各篇刊載內容。