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題名 | Cartilage Repair by Free Periosteal Grafts in the Knees of Pigs: A Histologic Study=利用游離的骨膜移植修補豬的膝關節軟骨面:組織學研究 |
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作者 | 王清貞; 陳俞志; 鄭修明; 陳維仁; 黃玄贏; Wang, Ching-jen; Chen, Chris Y. C.; Tsung, Shu-ming; Chen, Wei-jen; Huang, Hsuan-ying; |
期刊 | 臺灣醫學會雜誌 |
出版日期 | 20000400 |
卷期 | 99:4 2000.04[民89.04] |
頁次 | 頁324-329 |
分類號 | 416.61 |
語文 | eng |
關鍵詞 | 骨膜移植; 豬; 膝關節軟骨面; Cartilage defect; Cartilage repair; Periosteal graft; Autogenous graft; |
英文摘要 | Background and purpose: Periosteal grafts may result in cartilage formation and, therefore, have the potential to repair cartilage defects. We evaluated the histologic results of free periosteal grafts for the repair of full-thickness cartilage defects in pigs. Methods: A free autogenous periosteal flap from the proximal tibia was grafted to a size-matched, full-thickness articular defect on the lateral femoral condyle of the knees of 12 pigs. The same defect on the medial femoral condyle was used as a control lesion. Biopsies were performed at 4, 8, and 12 weeks after grafting. Results: The control lesions showed dense fibrous tissue with no evidence of cartilage-like tissues. The predominant tissues after grafting were mixtures of fibrous tissue, fibrocartilage, mesenchyme tissue, and occasional bone islands, but no cartilage tissue was identified. The tissue distribution did not change in the same knee from the week 4 to the week 8 biopsy; nonetheless, there were interindividual variations in tissue distribution. Conclusions: The results of this study do not support the use of free periosteal transplantation for full-thickness cartilage defects of the knee. |
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