頁籤選單縮合
題 名 | Greater Effects of Fluoxetine and Its Combination with (-)-Pindolol in Elevating Hypothalamic Serotonin in Rats during Dark Hours |
---|---|
作 者 | Dreshfield,Laura J.; Rocco,Vincent P.; Wong,David T.; | 書刊名 | 中國生理學雜誌 |
卷 期 | 40:2 1997.06[民86.06] |
頁 次 | 頁57-61 |
分類號 | 361.1 |
關鍵詞 | 5-HT眤 antagonist; 5-HT眤 reuptake inhibitor; Microdialysis; Behavioral activity; |
語 文 | 英文(English) |
英文摘要 | Administration offluoxetine (10 nig/kg i.p.) caused a significantly greater increase in extracellular5-HT levels in hypothalamus of rats adapted to a reverse light period (lights off 9:00 am - 9:00 pm) thanthose adapted to the regular cycle (lights off 6:00 pm-6:00 am). Sequential administration of theantagonist 5-HTiA/P-adrenergic receptors (-)-pindolol at 0.1, 0.3, 1, and 3 mg/kg s.c. significantlyenhanced the fluoxetine-induced elevation of 5-HT levels in both groups of rats. (-)-pindolol at 0.1 mg/kg potentiated the fluoxetine-induced elevation in 5-HT levels significantly higher in rats adapted to thereverse light cycle than in those accustomed to the regular light cycle. The greater effects of fluoxetineand the subsequent administration of (-)-pindolol in the reverse cycle group may relate to the differencein activity of 5-HT neurons in the dorsal raphe of conscious animals adapted to the two light periods. |
本系統中英文摘要資訊取自各篇刊載內容。