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題名 | Restoration of Sexual Behavior in Aged Male Rats by Intracerebral Grafts of Fetal Preoptic Area Neurons=大鼠胎兒視前區神經原之腦內移植可恢復年老雄鼠之性行為 |
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作者 | 洪淑慧; 畢萬邦; 蔡元奮; 彭明聰; Hung, Shu-huei; Pi, Wan-pang; Tsai, Yuan-feen; Peng, Ming-tsung; |
期刊 | 臺灣醫學會雜誌 |
出版日期 | 19971000 |
卷期 | 96:10 1997.10[民86.10] |
頁次 | 頁812-818 |
分類號 | 415.149 |
語文 | eng |
關鍵詞 | 大鼠; 胎兒; 視前區神經原; 腦內移植; 性行為; Copulatory activity; Fetal brain graft; Luteinizing hormone; Aging; Preoptic area; |
英文摘要 | A decline in sexual arousal and copulatory activity has been observed in male rats with advancing age. Grafting of fetal hypothalamic tissue into the third ventricle of aged male rats restores sexual behavior. This study investigated the effects of grafting fetal preoptic area (POA) neurons into the POA of aged male rats exhibiting decreased sexual behavior. We grafted suspensions of fetal POA neurons into the POA of 20 aged (19 to 24 months old)male rats that displayed no ejaculation. From 2 weeks after grafting, one or more series of male copulatory activity and sexual motivation tests were performed at intervals of 3 to 4 weeks. Three behavioral tests given 5 days apart were repeated for each animal in each series. Among the 20 aged rats with the fetal grafts, 15 showed improved sexual motivation, and 14 of these had copulatory activity restored to levels comparable with those of young males. Among these 14 rats, eight ejaculated during copulation. Copulatory behavior was restored between 21 and 45 days after grafting and persisted until the end of observation (2-4.5 months). Sexual performance did not improve in control aged male rats grafted with either fetal cerebral cortex neurons into the POA or POA neurons into the ventromedial hypothalamus. The rats that received grafts of fetal POA neurons into the POA and recovered sexual performance also showed improvement or recovery to levels comparable to those in young males of serum testosterone concentrations, serum luteinizing hormone levels after castration, and the post-castration rise in luteinizing hormone. These results indicate that decreases in copulatory activity, sexual motivation, and some neuroendocrine functions in aged male rats are at least partially due to dysfunction of the POA. |
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