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題名 | Plasma Leptin Concentrations are Related to Body Fat Mass and Gender but not to Thyroid Dysfunction=血漿中瘦體素 (Leptin) 濃度不受甲狀腺功能異常影響但與體脂肪量及性別有關 |
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作者 | 宋育民; 許惠恆; 李文珍; 吳崇榮; 高嘉鴻; Song, Yuh-min; Sheu,Wayne Huey-herng; Lee, Wen-jane; Wu, Chung-jung; Kao, Chia-hung; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 19990300 |
卷期 | 15:3 1999.03[民88.03] |
頁次 | 頁119-126 |
分類號 | 415.593 |
語文 | eng |
關鍵詞 | 血漿; 瘦體素; 濃度; 甲狀腺功能異常; 體脂肪量; 性別; Body fat mass; Leptin; Thyroid dysfunction; |
中文摘要 | 瘦體素(Leptin)是近年來被廣泛研究的一種由脂肪細胞製造及分泌出來的蛋白質,在動物及人體中已被證實與體脂肪儲存量、能量消耗、及體重變化有密切相關性。甲狀腺功能疾患已知會產生前述症狀,但是有關人類甲狀腺功能疾患與血漿中瘦體素濃度相關性之研究極少同時討論其他可能影響瘦體素濃度因素之相關性。 本實驗總共收納了 134 位不同甲狀腺功能之病患:甲狀腺高能症 50 位,甲狀腺低能症 24 位,正常甲狀腺功能者有60 位。結果發現:血漿中瘦體素濃度並未因不同之甲狀腺功能狀態而有差異(平均值±標準差,分別為:甲狀腺高能症組:8.5 ± 5.4 ng/ml,甲狀腺低能症組:8.4 ± 4.7 ng/mg,及正常甲狀腺功能組:7.3 ± 4.5 ng/ml)。 當性別因素列入分析時,發現血漿中瘦體素濃度在女性為男性之二倍, 此明顯差異可見於所有受試者皆納入分析(女性與男性比:8.8 ± 4.9 ng/ml:4.1 ± 2.1 ng/mg,p<0.001),或當不同甲狀腺功能者分組分析時(分別為: 女性與男性比: 甲狀腺高能症組:9.7 ± 5.5 ng/ml:4.3 ± 2.1 ng/ml,p<0.001;甲狀腺低能症組:9.7 ± 4.6 ng/ml:4.4 ± 2.4 ng/ml,p=0.015;及正常甲狀腺功能組:7.9 ± 4.5 ng/ml:3.6 ± 1.9 ng/ml,p=0.013)。血漿中瘦體素濃度在兩性皆與體脂肪量(女性:r=0.47, p<0.001; 男性:r=0.71, p<0.001)及體質比(女性:r=0.51,p<0.001;男性:r=0.78,p<0.001)有密切之正相關性。 結論血漿中瘦體素濃度與性別有關,並且與體脂肪量及體質比呈正相性之變化。甲狀腺功能異常並未影響血漿中瘦體素之濃度。 |
英文摘要 | Leptin, a newly defined protein synthesized and secreted from fat cells in both animals and humans, has gained wide attention. Many studies have been conducted on its roles in the regulation of body fat storage, energy expenditure and body weight changes. Thyroid dysfunction is known to have influences on the above changes in humans and these changes may in turn lead to a variation in circulation leptin levels. In addition, a sex dimorphism of plasma leptin levels has been a constant finding in many studies. However, the relationship between body fat mass and gender to plasma leptin levels in patients with various thyroid dysfunction has been rarely discussed together. A total of 134 patients with various thyroid function status were included in this study (hyperthyroidism: n=50, hypothyroidism: n=24, and euthyroidism: n=60). Plasma leptin concentratinos were compared between different thyroid function groups, and compared with body fat mass and body mass index (kg/m2 ) to check if these two parameters affect the circulating leptin levels. There were no significant differences between plasma leptin concentrations in the different thyroid function groups (Mean ± SD:hyperthyroidism: 8.5 ± 5.4 ng/ml, range: 1.5-25.8; hypothyroidism: 8.4 ± 4.7 ng/ml, range: 1.8-20.1, and euthyroidism: 7.3 ± 4.5 ng/ml, range: 0.6-20.9). Rather, a significant gender difference was found, with female subjects having two-fold higher levels than males when all study subjects were encompassed (female: 8.8 ± 4.9 ng/ml, range: 11.7-25.8 vs male: 4.1 ± 2.1 ng/ml, range 0.6-8.1, p<0.001) or when thyroid function status was analyzed separately (hyperthyroidism: female: 9.7 ± 5.5 ng/ml vs male: 4.3 ± 2.1 ng/ml, p<0.001; hypothyroidismL female: 9.7 ± 4.6 ng/ml vs male: 4.4 ± 2.4 ng/ml, p=0.015; and euthyroidism: female: 7.9 ± 4.5 ng/ml vs male: 3.6 ± 1.9 ng/ml, p=0.013). Plasma leptin concentrations had strong correlation with body fat mass in both females (r=0.47, p<0.001) and males (r=0.71, p<0.001). Good correlation was also observed between plasma leptin concentrations and body mass index in females (r=0.51, p<0.001) and males (r=0.78, p<0.001) . Plasma leptin concentrations were not different in thyroid dysfunction. A significant gender difference existed and a positive correlation between body fat mass and BMI to plasma leptin was observed. |
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