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題名 | Combined Interferon-α and Inosiplex Treatment of Subacute Sclerosing Panencephalitis: A Case Report=亞急性結節性泛腦炎合併腦室內注射甲型干擾素及口服Inosiplex治療--病例報告 |
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作者 | 韓其源; 林秀芬; 施邦英; 劉景寬; 劉景勳; Han, Chy-yuan; Lin, Hsiu-fen; Shin, Pang-ying; Liu, Ching-kuan; Liu, Chiang-shin; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 20030800 |
卷期 | 19:8 2003.08[民92.08] |
頁次 | 頁416-420 |
分類號 | 415.9 |
語文 | eng |
關鍵詞 | 亞急性結節性泛腦炎; 甲型干擾素; Subacute scleosing panencephalitis; Interferon-α; Inosiplex; |
中文摘要 | 本文為一位 15 歲男孩罹患亞急性結節性泛腦炎(SSPE)之病例報告。患者在住院後,經由臨床表現、腦波、脊椎液分析與腦組織病理等檢查確認診斷。最初的臨床表現,為在校成績減退與人格改變,而後八個月內漸進式肌躍症不自主的運動、智能障礙,並迅速持續退化。在給與患者口服 inosiplex 與腦室注射干擾素後,病情終於慢慢穩定,且神經失能指數(NDI)有上升的現象。在治療期間除了開始時有持續數天的體溫升高外,並沒有其他嚴重的副作用發生。口服 inosiplex 與腦室注射干擾素合併使用為一安全及有效的療法。疾病的早期發現與積極治療應該被強調與重視。 |
英文摘要 | Subacute sclerosing panencephalitis (SSPE) is rare in Taiwan. On admission to hospital, a 15-year-old boy was diagnosed with SSPE based on the clinical picture, electroencephalogram, cerebrospinal fluid studies, and brain biopsy. The initial clinical picture was a decline in school performance and a change in personality, followed by progressive tic-like involuntary movements and mental impairment for 8 months, then a rapidly progressive course. After the patient was treated with oral inosiplex and intraventricular interferon-alpha (IFN-alpha), his condition stabilized and the neurologic disability index score improved slightly. There were no major side effects during treatment except for a transient initial elevation of body temperature that lasted for several days. Oral inosiplex and intraventricular IFN-alpha appear to be safe and effective. Early identification and aggressive treatment of SSPE is important. |
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