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題 名 | Arginine Methylation of a Glycine and Arginine Rich Peptide Derived from Sequences of Human FMRP and Fibrillarin=富含甘胺酸及精胺酸蛋白序列胜冴之精胺酸甲基化 |
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作 者 | 艾麗霜; 林佳慧; 謝明麗; 李娟; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 23:4 1999.10[民88.10] |
頁 次 | 頁175-180 |
分類號 | 414.8 |
關鍵詞 | 甘胺酸; 精胺酸; 蛋白序列; 胜冴; 甲基化; Arginine methylation; Methylarginine; RGG proteins; |
語 文 | 英文(English) |
英文摘要 | N-methylation at the arginine residues in RNA binding proteins with the arginine and glycine rich RGG box has been identified. We show that a synthetic peptide R9 (GGRGRGGGF) with the RGG sequence present in human fibrillarin and fragile X mental retardation protein (FMRP) can be specifically methylated by rat brain extract. A control peptide K9 with all arginines replaced by lysines could not be methylated under the same conditions, indicating that the arginines in the peptide were the methylation sites. A novel missense mutation, which changes an arginine to a histidine in the RGG box region of FMRP in a typical fragile X patient, has been identified. A synthetic peptide with this Arg? His (GGRGHGGGF) substitution was methylated by our in vitro methylation system to a much less extent. Amino acid analysis of the methylated R9 peptide identified the methylated amino acid as monomethylarginine. The R9 peptide may be useful for further studies on arginine methylation in RGG proteins. |
本系統中英文摘要資訊取自各篇刊載內容。