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相關文獻
- Thyroid Function in the Sick Very Low-Birth-Weight Infants
- 極低出生體重早產兒甲狀腺功能之研究
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頁籤選單縮合
題 名 | Thyroid Function in the Sick Very Low-Birth-Weight Infants=極低出生體重早產病兒甲狀腺功能之研究 |
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作 者 | 許瓊心; 張瑞幸; 李燕晉; 洪漢陽; 高信安; 黃富源; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 40:4 民88.07-08 |
頁 次 | 頁237-242+288 |
分類號 | 417.5171 |
關鍵詞 | 低甲狀腺素血症; 甲狀腺素; 極低出生體重嬰兒; Hypothyroxinemia; Thyroxine; Very low-birth-weight infants; |
語 文 | 英文(English) |
中文摘要 | 本研究的目的在於探討極低出生體重早產兒出生後甲狀腺功能的變化。針對100 名極低出生體重的早產兒,在新生兒期進行一系列的血中甲狀腺素ththyroxine(T□)、游 離甲狀腺素free T□、三碘甲狀腺素triiodothyronine(T□)、甲狀腺激素thyroid- stimulating hormone(TSH)的檢測。共有89名參與研究的早產兒存活至出院,11名於住院 期間死亡。有41名(46.1%)存活者發生暫時性的低甲狀腺素血症。有1名存活的早產兒罹患 原發性甲狀腺低能症。其他88名存活者的資料分析顯示,在6個星期的研究期間,平均血 中TSH濃度都在正常範圍內。血中T□及freeT□的濃度則在出生1天以後下降,於7天時 達到最低點,之後持續上升。臍帶血中的T□濃度相當低,出生後血中的T□濃度則隨時間 而持續上升。本研究也發現,低下的T□血中濃度與病人死亡及罹病情形有關。低甲狀腺素 血症與病人危急的病況有所關聯。總結而言,極低出生體重早產兒出生後之甲狀腺功能變化 是相當特別的,暫時性低甲狀腺素血症常發生在這群病人身上。甲狀腺功能與死亡,新生兒 疾病及其後神經發展預後之間的關係則需要更進一步的研究。 |
英文摘要 | This study was undertaken to determine postnatal changes in thyroid function in very low-birth-weight (VLBW) infants. A total of one-hundred VLBW infants participated. Serial examination of serum levels of thyroxine (T4□, free T□, triiodothyronine (T□), and thyroid-stimulating hormone (TSH) was performed in the neonatal period. A total of eighty-nine infants survived to discharge, while eleven died during hospitalization. Transient hypothyroxinemia was found in forty-one (46.1percent) of the survivors. One of the surviving infants had primary hypothyroidism. His data was excluded from the analysis. In the other eighty-eight surviving infants, TSH levels were within normal limits throughout the six-week study period. T□ and free T□ values decreased after the first day of life, reaching a nadir at one week of age, followed by progressive increases. The mean cord blood T □ level was very low; the serum T□ value increased progressively in the postnatal period. We found a correlation between low T□ and free T□ values and mortality and neonatal illness. Hypothyroxinemia was associated with critical illness. In conclusion, the postnatal changes in thyroid function in VLBW infants were characteristic, with transient hypothyroxinemia being common in these infants. Further investigation of the relationship between thyroid function, death, neonatal illness, and developmental outcome is warranted. |
本系統中英文摘要資訊取自各篇刊載內容。