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題名 | 糖尿性腎病異常性脂蛋白血症之治療=Diabetic Kidney Disease: The Role of Dyslipoproteinemia and Treatment Guidelines |
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作者 | 王美珠; 蔡淑貞; 王郁青; 李隆志; Wang, Mei-chu; Tsai, Shu-chen; Wang, Yu-chin; Li, Lung-chin; |
期刊 | 藥學雜誌 |
出版日期 | 20160900 |
卷期 | 32:3=128 2016.09[民105.09] |
頁次 | 頁81-86 |
分類號 | 415.6685 |
語文 | chi |
關鍵詞 | 異常性脂蛋白; 糖尿性腎病; Statins類藥物; |
中文摘要 | 異常性脂蛋白血症普遍存在於糖尿性腎病人,尤其患有心血管相關疾病的病人, 更易增加死亡率和合併症。糖尿性腎病常合併有高膽固醇血症、低的高密度脂蛋白、 高的低密度脂蛋白。研究發現因高血脂易造成蛋白尿、腎臟功能異常和末期腎病。糖 尿性腎病的主要特徵是糖尿性腎絲球病變和相關的蛋白尿。在糖尿性腎病中造成腎絲 球硬化的主要機轉是腎絲球動脈硬化。在藥物治療方面,statins 類藥物使用在糖尿性 腎病中,可防止蛋白尿產生和腎功能異常。使用降低血液中低密度脂蛋白與膽固醇 的 statins 類藥物,雖可減少動脈硬化的程度,但卻無法減少糖尿性腎病病人死亡率的 發生。因此本篇文章是探討在糖尿性腎病的患者經由病理機轉和臨床試驗的研究,來 分析異常性脂蛋白血症的相關事宜,同時一起討論有關處理非高血壓性糖尿病的尿蛋 白,以避免腎功能的惡化。 |
英文摘要 | Dyslipoproteinemia is common in people with diabetic kidney disease (DKD). Cardiovascular events are frequent causes of morbidity and mortality in this population. DKD is associated with hypercholesterolemia, lower high-density lipoprotein (HDL), and higher low-density lipoprotein (LDL). The previous studies have shown that hyperlipidemia may be associated with albuminuria, renal dysfunction, and end-stage renal disease (ESRD) in the general population, and especially in DKD patients. Diabetic glomerulopathy and the related albuminuria are the main manifestations of DKD. The glomerular atherosclerosis is the main mechanism of glomerulosclerosis in DKD. The use of statins prevents the development of albuminuria and renal function impairmen in DKD. Treatment with statins reduces both serum LDL and cholesterol levels and decreases atherosclerosis, but does not reduce mortality. We will discuss the association of dyslipoproteinemia with DKD in pathogenesis and clinical trials, and the management of albuminuria in normotensive patients with diabetes. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。