頁籤選單縮合
題名 | Investigation of the Interaction between Crospovidone with Nifedipine and its Application=探討Crospovidone和Nifediopine之間的交互作用及其應用 |
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作者 | 嚴淑楊; Yen, Shu-yang; |
期刊 | 鄭氏藥學文教基金會研究彙刊 |
出版日期 | 19990300 |
卷期 | 3:1 1999.03[民88.03] |
頁次 | 頁147-152 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | 溶媒沉積法; 溶離速率; |
中文摘要 | 溶媒沉積法可有效地改善難溶性藥品的溶離速率。先前的研究發現在nifedipine和Kollidon CL所形成之溶媒沉積系統中,nifedipine之溶離速率增加許多。熱分析結果發現在這系統中 nifedipine 和 Kollidon CL 之間有交互作用存在。 因此本研究進一步探討了在高溫高濕度之環境下這系統的分子形態及其溶離安定性。 X 光繞射儀,電子顯微鏡及熱分析儀被用來研究nifedipine和KollidonCL之間的交互作用。結果發現在nifedipine和 Kollidon CL溶媒沉積系統中,nifedipine的分子會變成不定形而進入Kollidon CL分子之孔洞中。當這系統暴露在75% RH和50℃的環境下三個月後,nifedipine分子形成結晶。因此它的溶離速率下降,但這分子仍在Kollidon CL分子孔洞內。 |
英文摘要 | Solvent deposition method was used to increase the dissolution rate ofa low solubility drug. Nifedipine-Kollidon C1 solvent deposition system was found to greatly increase the dissolution rate of nifedipine in our previous study. The differential scanning calorimetry (DSC) study of this system also indicated the interaction between Kollidon CL with nifedipine. In the study we investigated the nature and dissolution stability of this system against humidity and temperature. X-ray diffraction, scanning electronic microscophy SEM) and DSC were used to probe the interaction between nifedipine and Kollidon CL. We found that the nifedipine molecules were changed into amorphous form and entrapped inside the pores or caves of Kollidon CL in the nifedipine-Kollidon Cl solvent deposition system. When the nifedipine-Kollidon CL solvent system were exposed to 75% RH. at 50 ℃ condition for 3 months, the nifedipine molecules were changed back into crystalline form. Therefore, the dissolution rate decreased but the molecules were still inside the pores of Kollidon CL condition. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。