查詢結果分析
來源資料
相關文獻
- 鼻粘膜和息肉中嗜伊紅白血球陽離子蛋白之含量
- 嗜伊紅白血球及其毒性蛋白與慢性鼻竇炎之相關性
- 慢性鼻竇炎或鼻竇炎合併鼻息肉病人組織抹片嗜伊紅白血球增生與術後主客觀評估之間的臨床意涵
- Aspirin三徵--二例報告
- 嗜伊紅白血球血管炎--病例報告及文獻回顧
- 鼻息肉與鼻過敏的關係
- Chronic Eosinophilic Pneumonia--A Case Report
- Expression of Transforming Growth Factor-β[feb5]and α-Smooth Muscle Actin of Myofibroblast in the Pathogenesis of Nasal Polyps
- Increased Epithelial Cell Proliferation in Nasal Polyps
- 鼻息肉過敏因素之探討
頁籤選單縮合
| 題 名 | 鼻粘膜和息肉中嗜伊紅白血球陽離子蛋白之含量=Eosinophil Cationic Protein Content in Nasal Hucosa and Polyp |
|---|---|
| 作 者 | 邱國華; 廖嘉正; 蕭雅一; 范盛欽; 李寬容; | 書刊名 | 中華民國耳鼻喉科醫學雜誌 |
| 卷 期 | 34:3 民88.05-06 |
| 頁 次 | 頁219-222 |
| 分類號 | 416.852 |
| 關鍵詞 | 嗜伊紅白血球; 嗜伊紅白血球陽離子蛋白; 鼻息肉; 選擇性聚積; Eosinophil; Eosinophil cationic protein; Nasal polyps; Selective recrutiment; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 背景:嗜伊紅白血球是鼻息肉中最主要的發炎細胞,其所釋放的毒性蛋白—嗜伊紅 白血球陽離子蛋白(eosinophil cationic protein, ECP)會造成氣管、鼻竇等呼吸上皮損傷。 上皮傷害是鼻息肉形成的重要因素。下鼻甲幾乎不曾有鼻息肉產生,且已知鼻息肉比下鼻甲 黏膜組織含有較多可釋放ECP的嗜伊紅白血球。本文即欲定量分析ECP是否大量存在於鼻息 肉中。 方法:我們將11個經鼻竇炎手術採得之鼻息肉及17個經下鼻甲部份切除的下鼻甲黏膜組 織。經磨碎處理後,以瑞典Pharmacia公司的ECP螢光酵素免疫分析試驗(fluoroimmunoassay) 測定,換算為每公克重鼻組織中之ECP含量,並同時測定病患血液中ECP濃度。最後比較鼻 息肉與下鼻甲鼻組織中ECP含量有無明顯差異性。 結果:鼻息肉組之每公克鼻組織中ECP含量平均為578.5 ng,下鼻甲組為74.9ng,兩組 間p值0.039,至於血液中ECP濃度則無差異性。 結論:鼻息肉之ECP含量遠比下鼻甲者高,ECP可能在鼻息肉之病因形成上佔重要角色。 鼻組織ECP含量較血液中ECP濃度更能反應鼻部真正的狀況。 |
| 英文摘要 | Background:Accumulation of eosinophils is the most characteristic feature of nasal polyposis. Eosinophils and their toxic protein, eosinophil cationic protein (ECP), can cause damage to respiratory epithelium. Epithelial damage is associated with initiation of mucosal polyp formation. The activated eosinophils, which can release ECP, are found in significantly higher numbers in nasal polyp tissue than in the inferior turbinate. Nasal polyps never originate from the inferior turbinate. We compared the ECP content of nasal tissue in the hypertrophic inferior turbinate (HIT) and in nasal polyps. Methods: Nasal tissues were obtained from specimens from patients having a partial inferior turbinectomy (n=17) or functional endoscopic sinus surgery (n= 11). The nasal tissue was ground to a powder in liquid nitrogen. The powder was then dissolved in PBS buffer (phosphate buffered saline, pH 7.4). After centrifugation, the aqueous layer was transferred to an Eppendorf tube and lyophilized by vacuum. The ECP content was detected with a Pharmacia ECP fluoroimmunoassay kit and the final ECP content was calculated per gram of nasal tissue. The serum ECP value was checked simultaneously. Results: The ECP content in nasal polyps (NP) (578.5 ng/g) was higher than that in the HIT (74.9 ng/g) (P<0.05); whereas the ECP value in blood was not significantly different between the NP and the HIT groups. Conclusions: A higher ECP content in nasal polyps than in the inferior turbinate implies that ECP may play a role in the pathogenesis of nasal polyps. |
本系統中英文摘要資訊取自各篇刊載內容。