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題名 | 農藥免賴得致胚胎畸形及其測試方法之建立=Setting up and Validation of Whole Rat Embryo Cultures in Pesticides |
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作者 | 呂水淵; 王順成; | 書刊名 | 中華民國獸醫學會雜誌 |
卷期 | 25:1 1999.03[民88.03] |
頁次 | 頁69-76 |
分類號 | 437.23 |
關鍵詞 | 致畸胎性; 大鼠; 生體外; Teratogenicity; Rat; In vitro; |
語文 | 中文(Chinese) |
英文摘要 | In order to set up the in vitro teratology for pesticides, we cultured the whole embryos of pregnant day 9.5 rats at 360C and 30 rpm incubator for 48 hours and compared the benomyl with bifenox in developmental score, morphology, and medium pH. Abnormalities induced by benomyl were microphthalmia, anophthalmia, prosencephalic hypoplasia, flat head, prosencephaiic blisters, head or trunk necrosis, abnormal axial rotation, short and blunt trunk, cloacal extrophy, dorsally trunk and hind brain splited, fore brain and trunk splited, mid-hind brain splited. The results showed that yolk sac diameter, crown-rump length, head length, developmental score, somite number, dead or atrophy and abnormal rate were treatment-related in benomyl but not in bifenox. Based on the consistency of results in in vivo and in vitro for benomyl and bifenox we concluded that in vitro assessment for teratology served as a screen of the teratologic potential of pesticides in rats. |
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