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題名 | Rheologic Determinant Changes of Erythrocytes in Binswanger's Disease=Binswanger氏病人紅血球流變學及相關因素的研究 |
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作者 | 陳春富; 賈海燕; 馬煥文; 王丹影; 郭述蘇; 典伸; Chen, Chun-fu; Jia, Hai-yan; Ma, Huan-wen; Wang, Dan-ying; Guo, Shu-su; Qu, Shen; |
期刊 | 中華醫學雜誌 |
出版日期 | 19990200 |
卷期 | 62:2 1999.02[民88.02] |
頁次 | 頁76-85 |
分類號 | 415.92 |
語文 | eng |
關鍵詞 | Binswanger氏病; 腦動脈硬化; 血管性痴呆; 紅血球; 膜; 血液流變學; Binswanger's disease; Cerebral arteriosclerosis; Erythrocytes; Hemorheology; Membrane; Vascular dementia; |
中文摘要 | 背景:Binswanger氏病與大腦的長穿動脈嚴重硬化有關,該病患者的腦血管對CO ,的反應能力很差,因而血液流變學此時在調節血流方面可能起到重要作用。本文觀察此類 患者紅血球流變學的變化,並探討紅血球與白質損害的關係。 方法:收納 Binswanger 氏病患者 28 例,並選取與患者年齡、腦血管危險因素等方面相配 之對照組。檢查他們的紅血球變形能力、膜流動性、紅血球聚集性、血漿粘度、全血粘度、 紅血球膜脂質及其亞組分約含量、膜唾液酸含量、丙二�j二醛含量及 ATP �t的活性。 結果:與對照組比較,患者紅血球變形能力及膜流動性均顯著下降,膜的磷脂醜乙醇胺、磷 脂醮膽�ヾB唾液酸的含量及 ATP �t活性也明顯降低; 而患者的紅血球膜膽固醇含量、膽固 醇與磷脂的比值、膜丙二�j二醛含量、血液粘度及紅血球聚集性則顯著升高。 結論:Binswanger 氏病患者紅血球膜的參數,尤其是膜磷脂,均存在看顯著的代謝異常, 並由此對紅血球流變行為產生影響。這些異常變化可能導致血液動力學發生障礙,從而促進 患者白質的損害。 |
英文摘要 | Background. Binswanger's disease (BD) has been associated with severe arteriosclerotii changes in the long perforating arteries and with impaired cerebrovascular responsivenes, to hypercapnia. Rheologic parameters may become important factors in regulating cerebra blood flow. The purpose of this study was to investigate the changes in rheologic deter minants of erythrocytes and to discuss the relation of erythrocytes and white matter lesions in this type of dementia. Methods. Twenty-eight patients suffering from BD and a control group matched for age sex and cerebrovascular risk factors were tested for the following hemorheologic variables: erythrocyte deformability, erythrocyte membrane fluidity, erythrocyte aggregation, plasma viscosity and whole blood viscosity. Additionally, red cell membrane metabolic parameters, lipids and individual membrane phospholipids, sialic acid (SA) and malondialdehyde (MDA) contents, and ATPase activities were measured. Results. A significant decrease in erythrocyte deformability, erythrocyte membrane fluidity, membrane phosphatidylethanolamine, membrane phosphatidylcholine, membrane SA and membrane ATPase activities, and a significant increase in membrane cholesterol, cholesterol to total phospholipid ratio, MDA, broad viscosity and erythrocyte aggregation were observed in BD patients when compared with those of the matched control group. Conclusions. Changes in erythrocyte membrane parameters, especially in phospholipids, can produce serious metabolic disorders and influence the rheologic properties of erythrocytes in patients with BD. These alterations can contribute to a circulatory slowdown and may lead to worsening of the condition of the cerebral white matter in these patients. |
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