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題名 | Free Radicals, Antioxidants and Infertility |
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作者 | Wu,Ko-yi; Tzeng,Chii-ruey; | 書刊名 | Journal of Reproduction and Infertility |
卷期 | 7:4 1998.12[民87.12] |
頁次 | 頁147-151 |
分類號 | 417.125 |
關鍵詞 | Free radicals; Reactive oxygen species; Infertility; Antioxidant; |
語文 | 英文(English) |
英文摘要 | Free eadicals, especially reacuive oxygen species(ROS),have a detrimental effect on germinal cills, Spermatozoa,oocyts and concepyi can ve danaged by free radicals which may fruther affect a pregnancy outcome, Free radicals also have a pathophysiological effect on ednonetriosis.ROS and iron concention have been shown to be hgher in the peritinead fluid of endemetrioses compared with the control,m and the activities of antioxidant enzymes such as catalase and glutathione reductase are increased to scavenge excessive ROS. Antioxidant theray could be an effective treatment in the prevention of 2-cell block and enhancement of blastocyst formation in an animal model. In humans, much evidence has also been found indivationg that the antioxidant therapy can effectively improve the sperm motility and subsequent reduction of DNA damage, Nevertheless, A prosprctive, colort studies are still neede to elucidate the long-term effects of antioxidant theraph on human oocyte or concepti. |
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