頁籤選單縮合
題名 | Human Parathyroid Hormone Effectively Stimulates Bone Formation= |
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作者 | Lee,Ta-chung; Shih,Chung; |
期刊 | 核子醫學雜誌 |
出版日期 | 19981000 |
卷期 | 11:4 1998.10[民87.10] |
頁次 | 頁99-104 |
分類號 | 415.596 |
語文 | eng |
關鍵詞 | Osteoporosis; Bone mineral density; Human parathyroid hormone; Bone cell; Osteogenesis; |
英文摘要 | Background: Osteoporosis is a disease with less bone tissue than normal and predisponse to fracture with minimal trauma. With aging, the decrease in bone mass (or bone mineral density) could cause osteoporosis or increase the occurrence of fracture. It ultimately involve all the soft tissues in the injured area as well as the bone, resulting in loss of function or even death. Therefore, investigations on keeping bone tissue and cells functionally and prevention of damage of bone structure are imperative in medicine. Recent evidences showed that there is significant increase in trabecular bone in osteoporotic patients treated with low dose parathyroid hormone (PTH). In addition, PTH could increase cortical bone volume and prevent postovariectomy osteopenia. However, the precise effect of PTH on bone formation is still unclear. The purpose of this study was to investigate the precise effect of low dose PTH on bone formation. Methods: BALB/C calvarial cell culture system, von Kossa staining, alkaline phosphatase activity assay, 3H-thymidine incorporation assay, collagen synthesis assay, bone histomorphometry and light microscopy were performed on fetal calvarial cells from 13-day timed-pregnant BALBIC mice. Results: Low dose hPTH significantly increase bone colony formation, osteoprogenitor cell proliferation and osteoblastic alkaline phosphatase activity. Conclusions: hPTH effectively enhance bone formation. |
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