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題名 | 中藥對過敏性鼻炎治療之免疫機轉研究=Immunologic Studies on Allergic Rhinitis Treated by Chinese Medicine |
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作者 | 楊賢鴻; 余家利; |
期刊 | 中醫藥年報 |
出版日期 | 19990500 |
卷期 | 17:3 1999.05[民88.05] |
頁次 | 頁63-80 |
分類號 | 413.52 |
語文 | chi |
關鍵詞 | 過敏性鼻炎; 免疫球蛋白E; 細胞激素; 嗜中性白血球; Allergic rhinitis; IgE; Cytokine; Neutrophil; |
中文摘要 | 本計劃目的在研究「過敏性鼻炎」患者,服用中藥混合複方(辛夷散,小青龍湯,香砂六君子湯)後,體內免疫機轉之影響,並進一步了解中藥對過敏性疾病的治療是否經由透過免疫調節來達到治療作用。 實驗中我們搜集50位患者包括「過敏性鼻炎」治療組28位患者,及對照組22位患者,治療組患者在臨床上有出現鼻子癢、打噴嚏、流鼻水、鼻塞等症狀,且經抽血檢查,血中過敏抗體IgE呈陽性反應。對照組患者為臨床上有類似過敏症狀,但血中過敏抗體IgE呈陰性反應。二組患者均接受藥物治療三個月,所有患者在治療前及治療後,分別接受臨床症狀指數評估,並檢測患者血中過敏抗體IgE的總量,細胞激素包括:(IL-4,IL-10,INF-γ)及嗜中性白血球的吞噬能力檢驗。 實驗結果發現實驗組,經中藥混合複方治療三個月後,臨床症狀在統計學上有有意義的顯著改善,且此種改善與血清中IgE的下降呈有意義正相關。此外,我們發現經中藥叉療的患者,細胞激素:INF-γ呈有意莪下降,IL-10呈有意義上升,而IL-4改變則不顯著。至於嗜中性白血球的吞噬能力則未受影響。所以我們認為,中藥混合複方對「過敏性鼻炎」患者治療三個月,可有效改善臨床症狀及降低血中IgE值,此作用是與體液媒介過敏反應的抑制有關係。此外中藥混合複方治療也有抑制細胞媒介過敏反應的作用,經由此作用可有效抑制過敏性鼻炎急性期的局部發炎反應,來達到治療作用。 |
英文摘要 | In this study, mixed prescription of Chinese medicine, including (Sing-Yi) Sang;Shaw-Shing-Long_Tang, and Shiang-Sa-Lieu-Gung-Gi- Tang) were treated to the patients of allergic rhinitis, in order to evaluate whether Chinese medicine can treat the allergic diseases through the mechanism of modulating human immunity. In our studies, 50 patients of allergic rhinitis were collected, 28 patients were in treatment group and 22 patients were in control group. All the patient suffered clinical symptom of nasal itching, smeezing. rhinorrhea and nasal obstruction before the study, patients with high serum IgE titer were put into study group, and low serum IgE titer were put into control group. All the patients accepted treatment of Chinese medicine for three months, and evaluation of smptomatic score, serum IgE, cytokines including (IL-4,IL-10,INF-γ) meutrophil phagocytosis function will he dome, before and after treatment. The results of our studies found, that after three months treatment, the study group showed statically significantly of clinical symptomatic release, this changes is related to decreaqsing of serum IgE titer. Further investigation of cytokines we found decreasing of INF-γ and elevation of IL-10 with statically significantly, but not for Il-4 level change and neutrophil phagocytosis. From these data, we found after three months tratment of Chinese medicine, can effectively improved the clinical symptoms of allergic rhinitis, decreased the serum IgE level, and inhibiting luman cell-mediated immunity, through this effect it is help for the patients who suffered acute attack of allergic rhinitis by inhibiting the local inflammation. |
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