頁籤選單縮合
題名 | Premenstrual Asthma: Report of a Case with Hormonal Studies=月經前氣喘: 一病例報告及賀爾蒙分析 |
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作者 | 林仙明; 黃守正; | 書刊名 | 微免與感染雜誌 |
卷期 | 31:3 1998.09[民87.09] |
頁次 | 頁197-199 |
分類號 | 417.1242 |
關鍵詞 | 經前症候群; 月經前氣喘; 賀爾蒙; Premenstrual asthma; Progesterone; |
語文 | 英文(English) |
中文摘要 | 一位39歲女性病人過去並無抽煙習慣,從29歲起便有氣喘發作,在13歲起更有過 敏性鼻炎。過去並無經前症候群症狀,當月經來前24小時,最大尖峰流速從正常的 350 L ╱ min, 急速下降至 200 L ╱ min。 每天類固醇的使用量從 prednisolone 10 mg 起,必需增加至 40 mg 才能維持正常的最大尖峰流速。 每天記錄最大尖峰流速及隔天測定 賀爾蒙包括黃體素及雌性素,發現黃體素及最大尖峰流速有正向相關。在月經前二天給予肌 肉注射黃體素 75 mg 後, 加上支氣管擴張劑及低劑量類固醇(每天 prednisolone 10 mg )便可有效控制月經前氣喘發作。本文提出月經前急速黃體素下降可能引起月經前氣喘發作 。 |
英文摘要 | We report a 39-year-old female non-smoker who has history of asthma since the age of 29 and history of allergic rhinitis at age 13. No symptomatic characteristics of premenstrual tension were reported. Forced expiratory peak flow rate (PEFR) readings showed striking falls 24 hours before menses, with the peak flows dropping from a baseline of 350 L/min to 200 L/min. The patient received 10 mg prednisolone daily which was increased to 40 mg prednisolone in the menstrual week in an attempt to maintain a normal peak flow. Daily peak flow readings and every other day hormonal studies of progesterone and estrogen both demonstrated a positive correlation between the serum progesterone and the peak flow readings. The addition of intramuscular progesterone (75mg daily) to the bronchodilators eliminated the premenstrual dips in peak flow, and daily doses of prednisolone were reduced to 5-10 mg. We suggest that a rapid fall in serum progesterone may play an important role in the pathogenesis of premenstrual asthma. |
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