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題名 | 臺灣市售易誤用、混用中藥品種之檢討(3)=Studies on the Commonly Misused, Adulterated Chinese Crude Drug Species in Taiwan(Ⅲ) |
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作者 | 張永勳; 何玉鈴; 高國清; 童承福; 邱年永; 謝明村; 蔡輝彥; 陳忠川; |
期刊 | 中醫藥年報 |
出版日期 | 19990500 |
卷期 | 17:2 1999.05[民88.05] |
頁次 | 頁55-90 |
分類號 | 414.33 |
語文 | chi |
關鍵詞 | 青黛; 靛玉紅; 靛藍; 指標成分; Ching-dai; Indigo; Indirubin; Indicating; Constituents; |
中文摘要 | 近年來政府積極推行中藥GMP政策,以提高中藥及中藥製劑水準。然而有些中藥材之基原頗為複雜,商品名稱及來源亦很混亂,且常有代用品或膺偽品充斥其間,因此有必要對基原較複雜之藥材加以釐清。去年度之計畫以板藍根、大青葉及青黛等藥材為對象,初步發現市售青黛二十種檢品中, 僅有四種含靛玉紅(indirubin)及靛藍(indigo)(兩種大陸、一種馬來西亞),其餘皆為藍色色素,嚴重影響臨床療效,值得全面檢驗臺灣市售青黛及含青黛製劑之定量分析。因此,本年度除繼續收集臺灣市售青黛檢品至30件外,並委託大陸學者代為收集大陸各地市場品計 23 件,另依文獻中以各種不同科局之原料進行青黛之製作, 並比較其成分含量,發現各檢品中成分含量差異極大,值得重視。青黛中之靛藍(indigo) 及靛玉紅(indirubin)近年研究發現具良好抗癌及抗菌作用,其乃為青黛之主成分, 可作為評估青黛及含青黛製胡品質之指標成分,其主成分靛藍(indigo)及靛玉紅(indirubin)不易購得,因此本年亦進行此二指標成分之分離製作及其高效液相層析方,之建立,以期對此青黛作有系統之分析,並將分離所得之指標成分教予中醫藥委員會,提供中醫界、中藥及界各中藥廠參考,做到「藥知痛用,醫知藥情」,以達到全面提昇中藥品質之理想。 |
英文摘要 | In recent years, the Chinese Governmen in Taiwan started GMP policies to elevate the quality standard of the Chinese crude drug preparations. However, the name and origin of some crude drugs are confusing. Substitution and adulteration are very common. Therefore it is essential to clarify the origins of those confused drugs. In the last year project, we investigated Ban-Lan-Gen (Isatidis Radix), Da-Ching-Yeh (Isatidis Folium), Ching-Dai (Indigo Naturalis) and the preparations containing those three herbs. The results showed that among the 20 Ching-Dai specimen collected from the Taiwan market, only four specimen contained indigo and indirubin which are the major ingredients of Ching-Dai. This phenomenon prompted us to further evaluation of the commercially available Ching-Dai and the preparationhs contained Ching-Dai. We also prepared the Ching-Dai from differed plant origin based on the previous reference and their chemical constituents were compared. Indigo and indirubin had been reported to exhibit antitumor and antibacterial activities and can be taken as indicating constituents for evaluating the quality of Ching-Dai and preparations contained Ching- Dai. Indigo and indirubin standard samples are not readily commercially available, therefore we analyzed the indigo and indirubin content of commercially available preparations and prepared indigo and indirubin in a large scale so as to able to provide pharmaceuilcal factories enough standards for their needs. This work will be helpful in elevating the quality standard of Chinese crude drug preparations in order to meet the theme of standardized formulas proposed by the Health Bureau of the Republic of China. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。