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| 題 名 | Characterization of Pulsatile Secretion of Gonadotropin and Prolactin in Women with Normalmenstrual Cycle,Secondary Amenorrhea and Polycystic Ovary Syndrome(Pcos)=正常月經、續發性無月經及多囊性卵巢症候群婦女之促性腺激素與泌乳激素之脈動性分泌特性 |
|---|---|
| 作 者 | 林國城; 李昭男; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
| 卷 期 | 14:2 1998.02[民87.02] |
| 頁 次 | 頁61-67 |
| 分類號 | 417.124 |
| 關鍵詞 | 促性腺激素; 泌乳激素; 脈動性分泌; Pulsatility; Gonadotropin; Prolactin; |
| 語 文 | 英文(English) |
| 中文摘要 | 為了解各種無月經婦女之下視丘、腦下垂體對月經之神經內分泌控制功能起見,正常月經卵泡初期婦女 (I群) 8名黃體素消退性出血陽性婦女 (II群) 10名及陰性無月經父婦女(III群) 8名,和多囊性卵巢症候群婦女 (IV群) 9名,共35名為主要研究對象。每位婦女於月經或消退性出血第五天住院,連續四小時每十五分鐘抽血,之後做了LH、FSH、PRL之激素測定。並分析各病例間LH、FSH和PRL脈慟性分泌之相關關系。四小時之LH脈動性分泌頻率,與I群相較,II群有相似之反應,而III群則顯示有意義的低下反應。但IV群則顯現出有意義的過度脈動性分泌反應。至於LH之分泌幅度,四群之狀況與脈動性頻率分泌狀況相似。而FSH之脈動性頻率分泌在III群及IV群均顯示較I群有意義的低下。但是PRL之脈動性分泌頻率及幅度,四群之間皆類似。以上研究結果顯示,LH、FSH、PRL之脈慟性分泌可能是經由共同的神經分泌路徑來控制。而異常之LH、FSH脈動性分泌可能與月經異常之發生機轉有相當密切的關係。 |
| 英文摘要 | To characterize the episodic fluctuations of serum LH, FSH and PRL in women with normally cycling, secondary amenorrhea and polycystic ovary syndrome (PCOS), four groups of women were studied: group I(N=8)consisted of normal women in the follicular phase of the cycle; group II (N=10) of women with secondary amenorrhea and positive progesterone withdrawal bleeding; group III (N=8) of women with secondary amenorrhea and negative progesterone withdrawal bleeding; group IV (N=9), women with polycystic ovary syndrome (PCOS). Blood samples were obtained at 15 minute intervals for 4 hours during one admission day. Ovarian steroids were measured to evaluate the baseline endocrine environment in each group. Distinct pulsatile fluctuations of serum LH, FSH and PRL were observed in all subjects. These pulses showed a high degree of coincidence in LH with FSH and LH with PRL in each group. However, the mean (±SD) frequencies of LH in group III and group IV were significatntly lower (P<0.01) and higher (P<0.01) than in group I, respectively. The mean frequencies of FSH in groups III and IV were lower (P<0.05), as compared with those of group. I The mean amplitude of LH in group IV was significantly higher (P<0.001) than in group I. These results suggest that loss of the regulatory pulsatility of gonadotropin release may be a contributory cause to anovulation and secondary amenorrhea. The concomitant pulsatile release of gonadotropin and PRL are essential to reproductive function and their regulatory controls in the follicular phase may be mediated through a common neuroendocrine mechanism in normal and hypogonaadal women. |
本系統中英文摘要資訊取自各篇刊載內容。