頁籤選單縮合
題名 | The Serum Concentrations of Procollagen Propeptides in Hypertensive Patients with or without Diabetes= |
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作者 | Wang, Yu-chen; Lee, Jen-kuang; Lin, Wei-cheng; Wu, Vin-cent; Hung, Chi-sheng; Liao, Lin-chu; Hsein, Yenh-chen; Kao, Hsien-li; Chao, Chia-lun; Wang, Tzung-dau; Lin, Yen-hung; Ho, Yi-lwun; Chen, Ming-fong; |
期刊 | Acta Cardiologica Sinica |
出版日期 | 20081200 |
卷期 | 24:4 2008.12[民97.12] |
頁次 | 頁198-203 |
分類號 | 415.382 |
語文 | eng |
關鍵詞 | PINP; PIIINP; Myocardial fibrosis; Hypertension; Diabetes mellitus; |
英文摘要 | Background: The serum concentrations of procollagen propeptides are valuable markers of myocardium collagen synthesis and turnover in hypertensive patients. The aim of our study was to evaluate the effect of diabetes mellitus on serum concentrations of procollagen propeptides in hypertensive patients. Methods: Sixty-three subjects admitted for coronary angiography were enrolled. All of the patients received analysis of the serum levels of the amino-terminal propeptide of types Ⅰ and Ⅲ procollagen (PINP and PIIINP). Results: Patients were divided into 3 groups according to the presence or absence of hypertension and diabetes; these were: 9 patients with both hypertension and diabetes (group 1), 38 patients with hypertension but without diabetes (group 2), and 16 normotensive patients without diabetes (group 3). Group 2 patients had higher serum PINP levels than group 1 and group 3 patients (p=0.023 and p=0.004, respectively). No significant difference of serum PINP level was noted between group 1 and group 3. However, the serum PIIINP level in group 1 patients was significantly higher than those in group 2 and group 3 (p=0.005 and p<0.001, respectively), and the serum PIIINP level between group 2 and group 3 showed no significant difference. Conclusion: Diabetic status influenced serum PINP and PIIINP levels differently in hypertensive patients. |
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