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題 名 | Breast Milk and the Prevention of Neonatal and Preterm Gastrointestinal Disease States: A New Perspective=母乳哺育及其預防新生兒與早產兒胃腸疾病之新展望 |
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作 者 | Walker,Allan W.; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 38:5 民86.09-10 |
頁 次 | 頁321-331 |
專 輯 | 母乳哺育 |
分類號 | 411.374、411.374 |
關鍵詞 | 母乳哺育; 新生兒; 早產兒; 胃腸疾病; Breast milk; Mucosal immuology; Necrotizing enterocolitis; Gastrointestinal alergy; Bacterial gastroenteritis m; |
語 文 | 英文(English) |
英文摘要 | In this review of the protective properties of human breast milk, a new perspective is taken to underscore the passive and active protection properties of breast milk in providing specific protection against selective gastrointestinal disease affecting the neonate and preterm infant. The normal protective properties of the gastrointestinal epithelial barrier (immunologic and nonimmunologic) are considered as is the development of barriers to antigen absorption in the immature infant human intestine as a background for considering three agerelated gastrointestinal diseases - necrotizing enterocolitis, intestinal allergy, and bacterial gastroenteritis. In each of these conditions, the developmental protective defect is considered and the role of breast milk plays in filling the protective void discussed. Besides considering passive protection of breast milk including the new roles assigned to nutrients such as lactoferrin and uncleotides, the importance of active substances in breast milk such as growth factors, cytokines and hormones are discussed in the context of actively stimulating the infant's own intestinal defenses to function as a protective barrier. Future studies at the cellular and molecular level should be helpful in designing both preventative and treatment strategies to deal with these diseases. |
本系統中英文摘要資訊取自各篇刊載內容。