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頁籤選單縮合
題名 | 放射線引起之外耳道軟骨肉瘤--病例報告=Radiation-Induced Chondrosarcoma of the External Ear Canal--Case Report |
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作者 | 季建華; 林書馨; 婁培人; Chi, Chien-hua; Lin, Hshu-hshing; Lou, Pei-jen; |
期刊 | 中華民國耳鼻喉科醫學雜誌 |
出版日期 | 19990900、19991000 |
卷期 | 34:5 民88.09-10 |
頁次 | 頁436-439 |
分類號 | 416.82 |
語文 | chi |
關鍵詞 | 放射線引起之肉瘤; 軟骨肉瘤; 外耳道; 鼻咽癌; Radiation-induced sarcoma; Chondrosarcoma; External ear canal; Nasopharyngeal carcinoma; |
中文摘要 | 放射線治療經常應用在鼻咽癌的治療中,但少有放射線治療引起繼發性耳癌的 例子。吾人近日經歷一45歲男性病患,8年前因鼻咽癌接受7000cGy的放射線治療,並合併 methotrexate及Endoxan的化學治療,之後鼻咽部無腫瘤復發。不幸日前出現左外耳道腫 脹疼痛的症狀,耳鼻喉局部檢查發現其軟骨性外耳道後壁出現一表面平整之腫瘤,經顳骨 切除術治療後之病理診斷證實為軟骨肉瘤。根據其發生的時間、位置、以及病埋組織形態 ,均符合放射線引起繼發性肉瘤的標準。檢索文獻,此外耳道軟骨肉瘤乃國內外首例,故 提出報告。 |
英文摘要 | Radiation therapy is the mainstay treatment for nasopharyngeal carcinoma (NPC). Nevertheless, the incidence of radiation-induced sarcoma ( RIS) remains low in patients with NPC, and radiation-induced chondrosarcoma has not been reported. Herein, we report the case of a 45-year-old man who developed radiation-induced chondrosarcoma in the cartilaginous ear canal eight years after receiving radiation therapy for an NPC. On admission, he complained of tenderness and swelling in the left ear canal. Physical examination revealed a smooth bulging mass originating from the cartilaginous ear canal. Lateral temporal bone resection was performed and pathological examination revealed chondrosarcoma. The post-operative course was smooth and no evidence of tumor recurrence was found during the follow- up of 8 months. The location of the tumor, the interval after previous irradiation, and the histological findings were all consistent with a diagnosis of RIS. To our knowledge, this is the first reported case of radiation-induced chondrosarcoma. Because early diagnosis of RIS offers the only chance for cure, early work-up of any fresh pain and swelling in an irradiated field is vital. |
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