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題名 | Bioactive Meroditerpenoids from a Formosan Marine Sponge Strongylophora durissima=臺灣產海綿活性mero-雙萜類之研究 |
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作者 | 沈雅敬; 林少陵; 杜昌益; 黃太煌; |
期刊 | 臺灣水產學會刊 |
出版日期 | 19951200 |
卷期 | 22:4 1995.12[民84.12] |
頁次 | 頁365-374 |
分類號 | 386.2 |
語文 | eng |
關鍵詞 | 海綿; Mero-雙萜類; 細胞毒性; 毒魚作用; Sponge; Strongylophora durissima; Meroditerpenes; Cytotoxicity; Ichthyotoxicity; |
中文摘要 | 利用生物活性為指標的分離法,自臺灣產的海綿Strongylophora durissima之酒精莘 取物中分離得到5個成份,Strongylophorine 1(1),2(2),3(3),7(4),8(5)。這些化合物的立體 化學結構是由光譜及化學方法建立的。生物活性分析結果顯示化合物1,2,7和8對老鼠淋 巴癌細胞(P-388)、人類鼻咽癌細胞(KB)、人類肺癌細胞(A549)、以及人類直腸癌細胞(HT-29) 均具有強大的細胞毒性作用。 |
英文摘要 | Bioassay-directed fractionation of the ethanolic extracts has resulted in the isolation of five strongylophorines 1(1), 2(2), 3(3), 7(4), 8(5) from a Formaosan marine sponge Strongylophora durissima. The structures of these compounds were established by spectral and chemical methods. Biological screening revealed that compounds 1, 2, 4 and 5 exhibited potent cytotoxicities against P-388 (murine lymphocytic leukemia), KB (human epidermoid careinoma), A549 (human lung adenocareinoma) and HT-29 (human colon adenocarchnoma) tumor cells. |
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