頁籤選單縮合
| 題 名 | Synthesis and Antiviral Activities of Heterocyclic Schiff Bases of Aminohydroxyguanidine |
|---|---|
| 作 者 | Das,Arima; Lien,Eric J.; Trousdale,Melvin D.; | 書刊名 | 中華藥學雜誌 |
| 卷 期 | 49:2 1997.04[民86.04] |
| 頁 次 | 頁89-102 |
| 分類號 | 418.1 |
| 關鍵詞 | Schiff bases of aminohydroxyguanidine; Synthesis; Antiviral activity; Herpes simplex; Adenovirus; S.A.R.; |
| 語 文 | 英文(English) |
| 英文摘要 | Two newly designed and synthesized Schiff basxes of aminohydroxyguanidine (SB-AHGs) were tested for antiviral activity against herpes simplex virus type 1 (HSV-1) and adenovirus type 5 (Ad 5) along with 11 other heterocyclic SB-AHGs. Three compounds I, VII and IX were moderately active again HSV-1 with IC �t values ranging from 24-52μM. Compounds I, VIII and XI had good anti-adenoviral activity with IC values ranging from 19-52 μM. Among the compounds tested, compound I had the highest selectivity indices of 10.2 (HSV-1) and 7.6 (Ad 5). |
本系統中英文摘要資訊取自各篇刊載內容。