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題名 | 平陽黴素對KB細胞的抑制機轉=Mechanism of Pingyangmycin in Inhibition of KB Cell Activity |
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作者 | 戴國維; 張育超; 周林世珍; 周明勇; Tai, Kuo-wei; Chang, Yu-chao; Chou Lin, Shin-shen; Chou, Ming-yung; |
期刊 | 中華牙醫學雜誌 |
出版日期 | 19971200 |
卷期 | 16:4 1997.12[民86.12] |
頁次 | 頁210-217 |
分類號 | 416.94 |
語文 | chi |
關鍵詞 | 平陽黴素; KB細胞; 化學治療; Pingyangmycin; KB cells; Chemotherapy; |
中文摘要 | 平陽黴素(pingyangmycin, bleomycin A�N��,PYM)為中國大陸地區從平陽鏈黴菌 (Streptomyces pingyangensisn) 所產生的多種成份中,開發出來的抗腫瘤抗生素藥物。平 陽黴素的化學結構與目前台灣或其他地區所使用的抗癌癌- bleomycin 近似; 但是二者在 末端支鏈的成份上有所差異。在本篇實驗中,我們利用多孔培養皿,細胞生長曲線等實驗方 法來探討平陽黴素對 KB 細胞毒性的作用;同時觀察細胞在藥物作用下型態上的變化。然後 我們利用 DNA 合成抑制試驗來評估平陽黴素可能的作用機轉。 實驗結果顯示: 當以 5 μ g/ml 濃度的平陽黴素作用 24 小時後, 可有效抑制 KB 細胞的生長, 抑制率達 63.9 % ( p<0.05);同時在顯微鏡下,細胞型態在藥物作用下呈現顯著變化。 另外,在相同的實驗條 件下,KB 細胞 DNA 的合成僅為對照組的 80.73% (p<0.05)。因此我們可以初步推論:在體 外試驗中, 平陽黴素能有效抑制腫瘤細胞的生長,而其作用機轉可能與抑制細胞 DNA 的合 成有關。 |
英文摘要 | The antitumor antibiotic pingyangmycin (PYM; bleomycin A�N) is produced by Streptomyces pingyangensisn. The chemical structure or PYM is similar to that of bleomycin (BLM), but their terminal amine moieties are different, and the mechanism of PYM inhibition of tumor growth has not been well studied. In this article, we used the multiwell / cell growth curve method to assess the inhibition KB cell growth by PYM; we also investigated the mechanism of tumor cell growth as well as the morphological variations of drug-treated cells. DNA synthesis inhibition assay was used to evaluate the antitumor mechanism of PYM. Treatment with 5 μ g/ml PYM for 24 hours significantly inhibited cell growth and synthesis of DNA (p<0.05). Therefore, it appears PYM exerts its inhibitory effect on KB cell growth by inhibiting synthesis of DNA. |
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